胱抑素C及其他诊断糖尿病肾病标志物效能比较

Comparison of the diagnosis diabetes efficacy of CystatinC and other markers

目的探讨血清胱抑素C及血肌酐、血尿素氮、血β2微球蛋白、尿微量白蛋白对于诊断早期糖尿病肾病的临床意义。方法选择130例糖尿病肾病患者,常规方法测定血肌酐、尿素氮、血β2微球蛋白、尿微量白蛋白,用乳胶颗粒增强免疫比浊法测定外周血胱抑素C。比较各观察指标受试者工作特征曲线下面积(AUCROC)。结果对于早期和临床期糖尿病肾病,胱抑素C的曲线下面积大于血肌酐、血尿素氮、血β2微球蛋白、尿微量白蛋白,且差异有统计学意义(P<0.05)。结论血清胱抑素C对于早期及临床期糖尿病肾病的诊断较血肌酐、尿素氮、血β2微球蛋白、尿微量白蛋白更为准确,是判断肾功能损害程度的敏感指标,对糖尿病肾病的早期诊断、治疗具有较高的临床价值。

Objective To investigate clinical significance of serum Cystatin C and serum creatinine,serum urea nitrogen,serumβ2-microglobulin,urinary albumin.Mothods 130 cases of patients with diabetic nephropathy were selected,serum creatinine,blood urea nitrogen,serum β2-microglobulin,urinary albumin were measured by routine method,Cystatin C concentration was determined using latex particle enhanced turbidimetry immunoturbidimetric assay（PETIA）.Results The AUCROC of Cys C was greater than the AUCROC of erum creatinine,serum urea nitrogen,serum β2-microglobulin,urinary albumin in early and clinical stage diabetic nephropathy（P 0.05）.Conclusion The serum cystatin C is more accurate than serum creatinine,urea nitrogen,serum β2-microglobulin,microalbuminuria in the diagnosis of early and clinical stage diabetic nephropathy.Therefore,serum cystatin C is a sensitive indicator to judge the degree of renal impairment which in the early diagnosis of diabetic nephropathy,treatment with high clinical value.