纳洛酮治疗新生儿缺氧缺血性脑病疗效分析

Analysis of the clinical efficacy of naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy

目的分析纳洛酮治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法将本科收治的44例HIE患儿随机分为两组,其中对照组21例采用常规治疗方法,观察组23例在对照组治疗的基础上静脉滴注盐酸纳洛酮注射液,比较两组患儿机体、神经功能恢复时间、临床疗效和神经行为测定(NBNA)分数。结果观察组机体和神经功能恢复时间显著短于对照组(P<0.05);临床疗效和神经行为测定(NBNA)分数显著高于对照组(P<0.05)。结论纳洛酮治疗新生儿缺氧缺血性脑病临床安全、疗效满意。

Objective To analyze the clinical efficacy of naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy （HIE）. Methods Forty-four cases of newborns with HIE were randomly divided into two groups, patients of the control group underwent conventional treatment, while patients of the observation group were given naloxone treatment on basis of conventional treatment. The recovery time of the body and neurological function, the clinical efficacy and the scores of NBNA were compared between two groups. Results The body and nerve function recovery time of the observation group was significantly shorter than that of the control group （P 0.05）, and clinical efficacy and neurobehavioral assessment （NBNA） score was significantly higher than that of the control group （P 0.05）. Conclusion Naloxone is efficient and safe in treatment of HIE.