胰岛素抵抗与前列腺增生的相关性研究

The association between insulin resistance and prostatic hyperplasia

目的探讨胰岛素抵抗与良性前列腺增生（BPH）发生发展的相关性。方法纳人我院老年科住院的男性患者150例。测量血压、身高、体质量、计算体质指数（BMI）。并检测空腹胰岛素（FINS）、空腹血糖、胰岛素抵抗指数（HOMA-IR）、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和前列腺特异性抗原（PsA）。超声测量及计算前列腺体积（PV）。结果胰岛素抵抗组（40例）患者PV和PV年增长率明显大于胰岛素敏感组（110例）患者（t=2．91，3．71；均P〈0．01）。随着患者FINS、HOMA—IR、PSA的增加，PV增大（t值分别为-3．02、-2．88、-2．84；均P〈O．05）。PV与胰岛素抵抗、FINS、PSA呈正相关（r分别为0．16，0．16，0．35；均P〈0．05）；PV年增长率与胰岛素抵抗、FINS、PSA、BMI成正相关（r分别为0．22，0．21，0．24，0．19；均P〈0．05）。结论胰岛素抵抗和高FINS是BPH发生发展的危险因素。

Objective To evaluate the relationship between insulin resistance and benign prostatic hyperplasia （BPH）. Methods Totally 150 male patient from the Department of Geriatrics in Peking University Hospital were included in this study. Blood pressure, body weight, body height, body mass index （BMI） were measured and calculated. Biochemical analyses including serum fasting levels of insulin（FINS）, glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and prostate-specific antigen （PSA） were performed. Total prostate volume （PV） were measured by ultrasound. Results PV and annual prostate growth rate were more increased in insulin resistance group（ 40 cases） compared with insulin sensitivity group（110 cases） （t=2.91, 3.71 respectively, both P（0.01）. Along with the levels of FINS, HOMA-IR and PSA were increased, the prostate volume was enhanced （t = 3.02, - 2.88, -- 2.84 respectively all P d0.05）. PV was positively correlated with insulin resistance, serum fasting insulin and PSA （r= 0.16, 0.16, 0.35;all P〈0.05）, while annual prostate growth rate was positively related with insulin resistance, serum fasting insulin, PSA and BMI （r= 0.22, 0.21, 0.24, 0.19; all P〈0.05）. Conclusions Insulin resistance and fasting insulin plays roles in the pathogenesis of prostatic hyperplasia.