摘要
目的探索理想的大鼠高脂血症动物模型造模方法。方法参考文献改进3种大鼠高脂配方,并制成高脂乳剂给大鼠灌胃,14 d后眦内静脉取血测定血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)的含量。结果三种高脂配方均不同程度的使大鼠血清中脂代谢紊乱。结论高脂配方3可在短时间内形成高脂血症大鼠模型。
Objective To explore the ideal experimental rats model for research on hyperlipidemia. Methods Three prescriptions on experimental hyperlipidemia-rats were modified and emulsion was made by references. At 14 day blood samples were taken from ocular orbit and content of TC.TG.LDL.HDL in the serum were measured. Results Three prescriptions could lead to the disorder of lipid metabolism at different levels. Conclusion Hyperlipidemia-rats model can be formed in a short time by prescription 3.
出处
《中国比较医学杂志》
CAS
2012年第9期55-57,共3页
Chinese Journal of Comparative Medicine
