PTTG在垂体腺瘤各亚型中的表达与分析

Expression of PTTG in pituitary adenoma

目的:研究PTTG与垂体瘤的各亚型的相关性。方法:用免疫组化方法检测92例垂体肿瘤病人PT-TG。其中29例GH,20例PRL,10例ACTH,11例FSH/LH,9例TSH和13例无功能腺瘤。结果:PTTG在细胞质内显著表达,各亚型中GH型是表达最高,PRL腺瘤表达最低,各亚型的阳性表达率与PRL亚型阳性表达率对比均有统计学意义。结论:重体腺瘤不同垂体亚型中PTTG的表达阳性率及表达强度不同,PTTG检测,可为早期诊断垂体腺瘤(GH、PRL、ACTH、FSH/LH、TSH)亚型和无功能型提供参考。

Objective：To study the relation between PTTG and pituitary tumor subtypes.Methods： Immunohistochemical teswas used to detect the expression of PTTG in 92 cases of pituitary cancer patients.Results： PTTG was high expressed in the cytoplasm.Subtypes of GH-type was the highest expression,PRL adenoma was the lowest.Conclusion： In different subtypes of pituitary tamor PTTG expression was different.