孟鲁司特钠联合布地奈德气雾剂治疗儿童哮喘的临床观察

Clinical Observation of Montelukast Sodium United Cloth Budesonide Aerosol Treatment of Asthma in Children

目的研究孟鲁司特钠以及布地奈德气雾剂治疗儿童哮喘的疗效。方法选择本院门诊和住院部儿童哮喘80例,随机分成治疗组和对照组,每组40例。治疗组在吸入布地奈德气雾剂400μg/d基础上加孟鲁司特钠咀嚼片,5mg/d,每晚顿服,共3月,并随访3个月。观察期间如有哮喘急性发作,加用β2受体激动剂。对照组除不用孟鲁司特钠咀嚼片外,其余与治疗组相同。结果治疗组每月日间、夜间发作次数、用β2受体激动剂的次数较对照组明显减轻,差异有统计学意义(P<0.01)。治疗组FEV1占预计值的百分比较对照组改善明显,差异有统计学意义(P<0.01)。观察期间暂无不良反应发生。结论孟鲁司特钠联合布地奈德气雾剂治疗儿童哮喘疗效优于单纯使用布地奈德气雾剂,可适用于经正规治疗而疗效不佳患儿。

Objective To investigate the curative effect of montelukast sodium and budesonide aerosol of childhood asthma. Methods To choose outpatient and inpatient hospital 80 cases of children with asthma were randomly divided into treatment group and control group, each 40 cases. Treatment group inhaled budesonide 400μg/d based on Jiameng Lu Division special sodium chewable tablets, 5 rag/d, per night serving Dayton, 3 months, and follow-up in March. The observation period is subject to acute asthma attacks, plus β2 agonists. Control group montelukast sodium chewable tablets do not have the rest with the same treatment group.Results In the treatment group, the times of asthma spasm and dyspnea in the night and the days, and the times of using short effective β2 adrenocept or agonist were less than in the control group, there were marked difference between two groups （P〈0.01）. In the treatment group, the rate of ameliorated FEVt were better than those in the control group, there were marked difference between two groups （P〈0.01）, and the adverse effects were reduced. Conelusion Montelttkast sodium connecting with budesonide curing childish asthma have powerful effect, which is better than that only by imbibing glucocorticoid. It can become a good method curing to those children, who used regular treatment but the treatment is not ideal.