六君丹参颗粒治疗气虚痰瘀型高血压合并颈动脉硬化临床研究

Clinical Study of Liujun Danshen Granules in Treating Hypertension Combined with Carotid Atherosclerosis of Qi-deficiency and Phlegm-blood Stasis Syndrome

目的采用中药六君丹参颗粒治疗高血压合并颈动脉硬化属气虚痰瘀型患者,观察其对临床症状、颈动脉内膜及血脂等相关因子的干预效果。方法采取随机对照的方法,将124例临床辨证为气虚痰瘀型高血压合并颈动脉硬化患者分为治疗组64例、对照组60例。对照组采用常规降压和降脂治疗,治疗组在对照组基础上加用六君丹参颗粒治疗,2组疗程均为6个月。通过对2组治疗前后临床症状、颈动脉内膜中层厚度(IMT)及斑块个数、血脂、血液黏稠度等实验室指标的观察,评价六君丹参颗粒的疗效。结果治疗组在改善乏力等临床症状上明显优于对照组,对左颈总动脉、左颈总动脉分叉部、左颈内动脉IMT的影响较对照组明显,降低总胆固醇的效果优于同期对照组,对全血黏度、血浆黏度的干预效果明显优于对照组。结论六君丹参颗粒治疗气虚痰瘀型高血压合并颈动脉硬化可以改善其临床症状,降低颈动脉内膜厚度,达到治疗颈动脉硬化的效果,并具有调脂作用。

Objective To observe the intervention effect of Liujun Danshen Granules on clinical symptoms,carotid intima,blood lipid and related factors of patients with hypertension combined with carotid atherosclerosis of qi-deficiency and phlegm-blood stasis syndrome.Methods With randomized controlled method,124 patients of hypertension combined with carotid atherosclerosis of qi-deficiency and phlegm-blood stasis syndrome were divided into the treatment group（64 cases） and the control group（60 cases）.The control group was given the conventional treatments of lowering blood pressure and cholesterol,the treatment group was given Liujun Danshen Granules additionally.The treatment course was six months.By observing the changes of clinical symptoms integral,carotid intima-media thickness（IMT）,plaques number,blood lipid,blood fibrinogen and other laboratory indexes of the two groups before and after treatment,the clinical effect of Liujun Danshen Granules was evaluated.Results Compared with the control group,the effects on clinical symptoms such as weakness,IMT of left common carotid artery,left common carotid artery bifurcation and left internal carotid artery,the whole blood viscosity and plasma viscosity,and TC of the treatment group were significant.Conclusion For patients of hypertension combined with carotid atherosclerosis of qi-deficiency and phlegm-blood stasis syndrome,Liujun Danshen Granules can improve the clinical symptoms,reduce the carotid intima thickness to treat carotid atherosclerosis,and lower blood lipid.