痛泻宁颗粒联合抗抑郁药物治疗腹泻型肠易激综合征50例

Tongxiening Granules Combined Antidepressant in Treating 50 Cases of Diarrhea-Predominant Irritable Bowel Syndrome

目的观察痛泻宁颗粒联合抗抑郁药物治疗腹泻型肠易激综合征(IBS)的疗效。方法将2010年9月至2012年4月医院确诊为腹泻型肠易激综合征患者的100例,随机分为两组,每组50例。对照组给予氟西汀治疗,治疗组在此基础上加用痛泻宁颗粒。观察治疗前后临床疗效。结果治疗组腹痛总有效率(98.00%)明显高于对照组(88.00%),腹泻总有效率(100.00%)也明显高于对照组(90.00%)。结论痛泻宁颗粒联合抗抑郁药物治疗腹泻型肠易激综合征疗效好,无明显不良反应,可在临床推广。

Objective To explore the clinical effects of Tongxiening Granules combined with antidepressants in the treatment of diarrhea- predominant irritable bowel syndrome. Methods 100 patients diagnosed as D-IBS in this hospital from September 2010 to April 2012 were randomly divided into 2 groups,50 cases in each group. The control group was treated with fluoxetine（Prozac）,while on this base the treatment group was added with Tongxiening Granules. The clinical efficacy before and after treatment were observed in the two groups. Results After treatment, the total effective rate of abdominal pain was 98.00% in the treatment group,which was significantly higher than 88.00% in the control group. The total effective rate of diarrhea was 100.00% in the treatment group,which was significantly higher than 90. 00% in the control group. Conclusion The clinical application of Tongxiening Granules plus antidepressants in treating D-IBS has good effect without obvious adverse reactions,which can be widely promoted in clinical practice.