摘要
目的:以新型辅料磺丁基醚-β-环糊精(SBE-β-CD)作为渗透活性物质制备盐酸氨溴索渗透泵片,并对其释药机制进行初步探讨。方法:考察不同的渗透压活性物质对药物释放的影响,并通过正交设计试验确定了最优处方。结果:SBE-β-CD与常用的渗透压活性物质相比,具有显著优越性,制备的渗透泵片体外释药速率稳定,符合零级释药方程,且12 h累积释药率达到85%以上。结论:SBE-β-CD可以作为一种新型渗透活性物质,且制备的盐酸氨溴索渗透泵片是以渗透泵为主要的释药机制。
Objective: To prepare osmotic pump tablets of ambroxol hydrochloride using sulfobutylether-β-cyclodextrin as an osmotically active substance,and to investigate the mechanisms of drug release from the osmotic pump tablets.Methods: Influence of different osmotically active substances on drug release was studied.The optimal formulation was selected by orthogonal experiment.Results: Compared to general osmotically active substances,SBE-β-CD had marked superiority.The release of ambroxol hydrochloride was stable,and accorded with zero order release.The cumulative release percentage at 12 h reached up to 85%.Conclusion: SBE-β-CD can be used as a new osmotically active substance.The main mechanism of drug release from osmotic pump tablets is osmotic pump.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2012年第18期2212-2216,共5页
Chinese Journal of New Drugs
基金
石药集团医药联合研究基金(c2011206172)
关键词
磺丁基醚-Β-环糊精
渗透活性物质
渗透泵片
释药机制
盐酸氨溴索
sulfobutylether-β-cyclodextrin
osmotically active substance
osmotic pump tablet
mecha-nisms of releasing drug
ambroxol hydrochloride