重复口服蔗糖对缓解新生儿疼痛安全有效

Repetitive oral sugar administration is safe and effective to relievie newborn pain

目的观察口服蔗糖溶液对缓解新生儿重复足跟采血所引起疼痛刺激的持续有效性。方法将入住新生儿重症监护病房的足月新生儿60例随机分为口服蔗糖溶液干预组和口服安慰剂对照组。经相应干预后均给予足跟采血的疼痛刺激，并连续3天相同操作，观察足跟采血时两组间新生儿疼痛评分和心率、血氧饱和度波动方面的差异。结果新生儿在足跟采血刺激时口服蔗糖溶液干预组（3．30±1．56）与对照组（4．87±1．20）相比，新生儿疼痛评分显著降低（t=4．39，P〈0．01）；干预组连续3天的疼痛评分之间无显著性差异（t=0．13，P〉0．05），而对照组第1天与第3天之间的疼痛评分比较差异有统计学意义（t=2．48．P〈0．05）．结论重复口服蔗糖溶液对于缓解新生儿疼痛安全有效．并且不会产生耐受性。

Objective To observe the persistent effect of oral sugar solution on relieving repetitive pain stimulus of newborns. Methods Sixty term newborn patients who were admitted into neonatal intensive care unit （NICU） were randomly divided into two groups： treatment group receiving oral sugar solution and control group receiving oral placebo instead. After intervention the pain stimulus of heel blood sampling were given and the same procedures were repeated for three days. The differences in newborn pain scoring evaluation, heart rate and blood oxygen saturation fluctuation between two groups were recorded. Results Compared with control group （4.87 ＋ 1.20）, the treatment group had significantly lower pain scores when they had heel blood sampling （ 3.30 ± 1.56 ） （ t = 4.39 ,P 〈 0.01 ）. There was no significant difference in pain scoring evaluation among successive three days in treatment group （ t = 0. 13, P 〉 0.05 ） , while the pain scoring evaluation at first day was statistically different from that at third day in control group （t = 2.48 ,P 〈 0.05 ）. Conclusion Repetitive oral sugar solution is safe and effective in relieving newborn pain, and no tolerance is observed in this study.