肥胖儿童脂代谢紊乱与血管早期病变关联分析

Relationship between disorders of lipid metabolism in obese children and early vascular diseases

目的探讨在肥胖儿童体内血管早期病变与脂类代谢紊乱间的关联性。方法选取西安市东郊第一职工医院2009年7月至2012年1月体检时诊断为肥胖的血脂水平有异常的100例为血脂异常组，同时选取诊断为肥胖的血脂水平正常的100例为血脂正常组，比较两组患儿的血压、血糖、颈内动脉内膜中层厚度的临床差异性。结果两组的颈总动脉内膜中层厚度各项数据比较差异均无统计学意义（均P〉0．05）；而左颈内、右颈内、双侧颈内内膜中层厚度均值比较差异具有统计学意义（t值分别为3．12、2．04、3．01，均P〈0．05）。结论肥胖儿童体内血管早期病变与脂类代谢紊乱间存在明显的关联性，如控制不及时，血管早期病变已在儿童期发生。

Objective To study the relationship between early vascular disease in obese children and disorders of lipid metabolism in vivo relevance. Methods One hundred obese children diagnosed with abnormal hpid level in physical examination in Xi＇ an Dongjiao First Workers Hospital from July 2009 to January 2012 were selected in study group. At the same period another 100 obese children with normal lipid level were included in normal group. Then the blood pressure, blood glucose and intima -media thickness （IMT） of two groups were compared. Results There was no significant difference in carotid artery IMT between two groups （ both P 〉 0.05 ）, but the differences in left IMT, right IMT and bilateral IMT were statistically significant （ t value was 3. 12, 2.04 and 3.01, respectively, all P 〈 0.05 ）. Conclusion There is correlation between early vascular diseases in obese children and lipid metaboJism disorders. If it is not controlled timely, early vascular disease would develop in childhood.