新生儿休克的预后分析

Analysis of the prognosis of neonatal shock

目的探讨不同病因导致的新生儿休克对预后的影响。方法选取新生儿休克病例70份，采用卡方检验、单因素分析及多因素Logistic回归方法对新生儿疾病造成休克的严重程度、预后及是否合并多脏器功能损伤等相关性进行回顾性分析。结果有67例纳入分析，合并外科疾病组16例，无外科疾病组51例；两组中重度休克分别为14例（占87．50％）和17例（占33．33％）,X^2=14．373，P〈0．01；两组中死亡或放弃治疗后死亡分别为12例（占75．00％）和23例（占45．10％），X^2=4．364，P〈0．05；合并两个以上脏器功能损伤的分别为14例（占87．50％）和23例（45．10％）,X2=9．641，P〈0．01；经单因素分析，合并外科疾病是新生儿休克预后的危险因素。结论新生儿休克合并有外科疾病时，易发展成重度休克，且易合并多脏器功能的损伤，预后差。

Objective To explore the influence of neonatal shock induced by different causes on prognosis. Methods Retrospective study of 70 cases with neonatal shock was conducted to analyze the relationship among severity of shock caused by neonatal diseases, prognosis and whether multiple organ injury was combined by using chi-square test, univariate and multivariate Logistic regression analyses. Results Altogether 67 cases were recruited, including combined surgical diseases groun （ n = 16） and non-surgical diseases group （ n = 51 ）. There were 14 （ 87.50% ） and 17 （ 33.33% ） cases of severe shock in combined surgical diseases group and non-surgical diseases group, respectively （X^2 = 14.373 ,P 〈0.01 ）, and 12 （75.00%） and 23 （45.10%） cases of death or death after withdrawal treatment in two groups, respectively （X^2 = 4. 364, P 〈 0.05 ）. Combining with multiple organ injury occurred in 14 patients （87.50%） and 23 patients （45.10%）, respectively （X^2 = 9. 641, P 〈 0.01 ）. Univariate analysis revealed that surgical diseases were the unfavoriate prognostic factors. Conclusion It is easy to develop severe shock and suffer multiple organ injury when neonatal shock is combined with surgical diseases, and the prognosis is poor.