派特灵治疗宫颈高危型人乳头瘤病毒感染的临床观察

Clinical observation of paiteling on treatment of cervicitis combined with high-risk HPV infection

目的探讨派特灵在高危型人乳头瘤病毒（HPV）感染的宫颈病变患者中的临床价值。方法2009年6月至2011年6月在南通市妇幼保健院宫颈门诊行宫颈高频电刀电圈切除术治疗，病理学诊断为宫颈上皮内瘤变Ⅱ-Ⅲ级，术后6个月细胞学、阴道镜检查正常而高危型HPV检测阳性未自然转阴患者40例，随机分为治疗组及对照组；治疗组给予派特灵局部上药，对照组不再进行任何干预治疗。停药3、6个月后再次进行细胞学及高危型HPV—DNA检测。结果治疗组停药3、6个月后抗HPV感染的总有效率为90．0％、90．0％，对照组总有效率分别为30．0％、35．0％，治疗组的疗效明显高于对照组（∥分别为3．779、3．751，均P〈0．01），3个月及6个月后治疗组HPV—DNA负荷量均较治疗前明显下降（‰分别为3．606、4．365，均P〈0．01），对照组无明显疗效（U0分别为0．947、1．407，均P0〉0．05），治疗HPV负荷的改善率明显高于对照组（U。=3．653，U2=3．147，均P〈0．01）。结论派特灵可用以治疗高危型HPV感染。

Objective To evaluate the clinical significance of paiteling on cervicitis combined with high-risk human papillomavirus （HPV） infection. Methods Between June 2009 to June 2011 at Cervical Outpatient of Nantong Maternity and Child Health Hospital, 40 women accepted the treatment of loop electrosurgical excision procedure（LEEP） and with pathological diagnosis of cervical intraepithelial neoplasia （CIN） I1-III. Six months later the evaluation of cytology and eolposeopy was normal but high-risk HPV-DNA was positive. They were divided into 2 groups： experimental group using paiteling locally and control group without any intervention. All patients got cytology and high-risk HPV-DNA detection again after 3 and 6 months after treatment. Results At 3 and 6 months after withdrawal of treatment, the total efficiency was 90% and 90% , respectively in experimental group, and that was only 30% and 35%, respectively in control group. The curative effect of experimental group was significantly higher than that of control group （X2 value was 3. 779 and 3.751, respectively, both P 〈 0.01 ）. Compared with that before treatment, the HPV-DNA load of experimental group downregulated singificantly at 3 and 6 month of treatment （ u0 value was 3. 606 and 4. 365, respectively, both P0 〈 0.01 ）, but the curative effect of control group was not obvious （ u0 value was 0.947 and 1. 407, respectively, both/Do 〉 0.0）. The improvement rate of HPV load was significantly higher than that of control group（ u1 = 3. 653, u2 = 3. 147,both P 〈 0.01 ）. Conclusion Paiteling can be used to treat high-risk HPV infection.