艾司西酞普兰治疗老年抑郁症疗效观察

Effect observation of escitalopram in the treatment of elderly depression

目的观察艾司西酞普兰治疗老年抑郁症的疗效。方法将60例老年抑郁症患者随机分为研究组和对照组各30例。研究组予以艾司西酞普兰口服治疗,对照组予以文拉法辛口服治疗,观察6周。于治疗前及治疗后第1、2、4、6周末采用汉密尔顿抑郁量表(HAMD)评定临床疗效,采用不良反应量表(TESS)评定不良反应。结果研究组治疗后第6周末总有效率为90.00%,对照组为83.33%,差异无统计学意义(P>0.05)。2组治疗后第1周末始HAMD评分低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05和P<0.01)。但2组治疗后第2、4、6周末HAMD评分比较差异均无统计学意义(P>0.05)。2组不良反应均轻微。结论艾司西酞普兰治疗老年抑郁症的疗效与文拉法辛相当,且起效较文拉法辛快,安全性高,依从性好。

Objective To observe the efficacy of escitalopram in the treatment of elderly patients with depression. Methods 60 patients were randomly divided into research group and control group, each of 30 cases. The research group took escitalopram orally ,while the control group took venlafaxine orally for 6 weeks. The clinical efficacies were assessed with the Hamilton Depression Scale （HAMD） and the adverse reactions were assessed with the Treatment Emergent Symptom Scale （TESS） before treatment and at the ends of the 1 st,2nd ,4th, and 6th week after treatment. Results After 6 week treatment, the total effective rate was 90% in the research and was 83.33% in the control group ,the difference of 2 groups were not sta- tistically significant（P 〉 0.05）. The HAMD scores lowered more significantly at the end of the 1st week in both groups compared with before treatment, and did more significantly in the research than in the control group at the end of the 1 st week, and the differences were statistically significant（ P 〈 0.05 ,P 〈 0.01 ）. But there were no significant differences of 2 groups at other time points （ P 〉 0.05 ）. The adverse reactions of both groups were mild. Conclusion Escitalopram has therapeutic equiva- lence to venlafaxine, but takes effects quicker and has higher safety and better compliance in the treatment of elderly depres-sion.