糖化血清白蛋白水平在急性冠脉综合征患者中的表达

Study on the expression of glycated serum protein in patients with acute coronary syndrome

目的观察不稳定性心绞痛(UA)和急性心肌梗死(AMI)患者糖化血清白蛋白(GA)和空腹血糖(FBG)、餐后2 h血糖(2 h PBG)及糖化血红蛋白(GHb)的相关性。方法随机选择UA患者(UA组,131例)与AMI(AMI组,139例)两组人群,并测定GA、FBG、2 h PBG、GHb指标。探讨UA和AMI之间各项指标的差异性。结果 AMI组患者GA、FBG及2 h PBG较UA组升高(P<0.05),且FBG及2 h PBG与GA呈显著正相关,而两组之间GHb比较差异无统计学意义(P>0.05)。结论本资料显示AMI组比UA患者具有更高的血糖水平,GA、FBG及2 h PBG能有效监测UA和AMI急性期的变化,从而预测高危人群不良事件的发生,及时采取相应措施,控制血糖,改善预后、降低死亡率。

Objective To observe the correlation of serum glycated albumin （GA） and fasting blood glucose （FBG）, postprandial 2 hours blood glucose （2 h PBG） and glycosylated hemoglobin （GHb） in the patients with unstable angina （UA） and acute myocardial infarction （AMI）. Methods The patients with unstable angina （UA group, 131 cases） and acute myocardial infarction （AMI group, 139 cases） were selected. GA, FBG, 2 h PBG, GHb were detected. And to explore the difference of indicators in the two groups. Results GA, FBG and 2 hPBG levels were significantly higer in patients with AMI than in patients with stable angina and controls （P 〈 0.05）; FBG , 2 h PBG and GA were significantly related, and GHb was no significant difference between the two groups （P 〉 0.05）. Conclusion The data shows that the patients acute myocardial infarction have higher glucose levels than the patients with unstable angina, GA, FBG and 2 h PBG can effectively monitor changes in the acute phase of UA and AMI, in order to predict the occurrence of adverse events in high-.risk groups, to take timely appropriate measures to control blood sugar, improve prognosis and reduce mortality.