阿立哌唑与喹硫平治疗首发精神分裂症的临床对照研究

A clinical comparative study in first-onset schizophrenia patients treated with Aripiprazole and Quetiapine

目的探讨阿立哌唑与喹硫平治疗首发精神分裂症的临床疗效。方法 63例首发精神分裂症患者,符合CCMD-3精神分裂症诊断标准,随机分成两组,分别使用阿立哌唑和喹硫平治疗,疗程共8周。采用阳性和阴性症状量表(PANSS)和不良反应症状量表(TESS)进行副反应评定。结果阿立哌唑组总有效率为93.55%,喹硫平组总有效率为90.63%,差异无统计学意义(P>0.05)。阿立哌唑组和喹硫平组两组患者治疗前后PANSS量表评分,差异无统计学意义(P>0.05);阿立哌唑组治疗前后相比,瘦素和三酰甘油水平升高,差异有统计学意义(P<0.05),喹硫平组治疗前后瘦素、催乳素、血糖和三酰甘油水平升高,差异有统计学意义(P<0.05)。结论阿立哌唑和喹硫平对首发精神分裂症疗效相当,但副反应表现有差异,前者优于后者。

Objective To study the clinical effects of Aripiprazole and Quetiapine in the treatment of first-onset schizophrenia. Methods 63 adult patients who were diagnosed as schizophreniain accordance with the CCMD-3 diagnosis standard were recruited in this study. All the cases were randomized into two groups and were treated with Aripiprazole and Quetiapine for 8 weeks. The positive and negative syndrome scale （PANSS） and treatment emergent side effect scale （TESS） were used to evaluate efficacy and adverse effects respectively. Results The significant efficacy rates of Aripiprazole was 93.55%, Quetiapine was 90.63%, there was no significant difference （P 〉 0.05）. Before and after treatment between Aripiprazole group and Quetiapine group, the PANSS score had no significant difference （P 〉 0.05）. The level of LEP and TG was elevated which were treated by Aripiprazole, the difference was statistically significant （P 〈 0.05）. The level of LEP, PRL, BG and TG was elevated which were treated by Quetiapine, the difference was statistically significant （P 〈 0.05）. Conclusion The curative effect of first-onset schizophrenia between Aripiprazole and Quetiapine is quite, but the adverse reactions are different, the former is better than the latter.