温度敏感型聚酯/聚乙二醇三嵌段生物可降解共聚物的降解性能及药物释放的影响因素研究进展

Research on Influence Factors on Degradation Property and Drug Release of Thermosensitive Polyester Block/Polyethylene Glycol Block Triblock Biodegradable Copolymer

温度敏感型生物可降解水凝胶作为一种注射缓释给药系统的新型载体已受到越来越多的关注,聚酯(A嵌段)/聚乙二醇(B嵌段)三嵌段共聚物是目前最常用的温度敏感型聚合物,具有良好的生物相容性和生物降解性。本文综述了聚乙二醇嵌段含量、聚酯嵌段种类、共聚物凝胶水溶液浓度、处方中添加剂、药物与共聚物分子间的作用力、载药量及制剂形状、介质pH及温度等因素对聚酯/聚乙二醇三嵌段共聚物降解速率及药物释放速率的影响,为聚酯/聚乙二醇三嵌段共聚物水凝胶注射剂开发过程中共聚物降解速率和药物释放速率的调节提供有价值的思路与科学依据。

Thermosensitive biodegradable hydrogel as a novel matrix of sustained-release injectable drug delivery system has gained an increasing attention. The polyester （A） block/polyethylene glycol （B） block triblock copolymer with good biocompatibility and biodegradation is one of the most commonly used thermosensitive polymers. The effects of some factors, including the content of polyethylene glycol block, the type of polyester block, the concentration of copolymer solution, the additive in formulation, the drug-copolymer interaction, drug loading, the shape of preparation, the pH value of medium and temperature, on the rates of copolymer degradation and drug release are reviewed in this paper. It provides useful idea and scientific basis for regulation of the rates of copolymer biodegradation and drug release in the R＆D process ofhydrogel injection.