急性胰腺炎血清降钙素原检测的临床意义

The clinical significance of the detection of serum procalcitonin in acute pancreatitis

目的探讨血清降钙素原(PCT)作为判断胰腺炎患者胰腺受损和感染严重程度指标的应用价值。方法对象为2010-04～2012-04收治的急性胰腺炎患者33例,平均32.9岁。将患者分为两组:水肿型(18例)和出血坏死型(15例)。用双抗夹心免疫发光法测定血清PCT含量。结果 33例急性胰腺炎患者血清PCT水平均较正常对照组(0.5±0.2 ng/ml)明显升高(P<0.01,P<0.001)。经治疗后,水肿型的PCT水平有不同程度下降,在发病第9天,已经降至正常范围,而出血坏死型的PCT水平仍高于正常值。结论测定血清PCT升高阳性率与浓度有助于判断急性胰腺炎患者胰腺受损和感染的严重程度。

Objective To explore the application value of serum procalcitonin （PCT） detection in the diagnosis of acute pancreatitis and bacterial infections. Methods Objects were 33 cases of patients with acute pancreatitis admitted from April 2010 to April 2012, an average of 32.9 years. Patients were divided into two groups ：oedema （18 cases） and bleeding necrosis type （15 cases）. A sandwich immune method was used to determine the content of serum PCT. Results 33 cases of acute pancreatitis patients serum level increased significantly （ PCT 0.5 ＋ / - 0.2 ng/ ml） than that of normal control group （ P 〈 0. 01 ,P 〈 0. 001 ）. After the treatment, oedema PCT level haddifferent rate of decline, and at day 9 had dropped to the normal range ; but the PCT level of bleeding necrosis type was still higher than normal. Conclusion Detection of the concentration of positive elevated serum PCT can help determine pancreatitis pancreas damaged and the severity of the infection.