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诺和龙与二甲双胍联合治疗2型糖尿病的临床观察

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摘要 目的探讨诺和龙和二甲双胍联合治疗2型糖尿病的疗效。方法开始量给予二甲双胍0.25g,2次/d,进餐时服用。瑞格列奈0.5mg,3次/d,进餐时口服,依据血糖变化调整剂量,二甲双胍最大剂量2g/d,瑞格列奈最大剂量9mg/d,并且依据标准体重、工作性质和参照原来的生活习惯制定患者适合的食谱与运动量,共观察12周。结果 60例患者达到有效控制55例,控制不良5例,总有效率91.67%。治疗后空腹血糖及三餐后2h血糖均显著低于治疗前,差异有统计学意义(P<0.05),体重指数(BMI)无明显变化,差异无统计学意义(P>0.05)。结论诺和龙联合二甲双胍能有效控制2型糖尿病患者血糖,而且不良反应少、患者耐受性好。
作者 王菁
出处 《中外医疗》 2012年第26期115-115,117,共2页 China & Foreign Medical Treatment
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  • 1李霞,周智广,黄干,陈小燕,颜湘,杨琳,王建平.罗格列酮对低滴度谷氨酸脱羧酶抗体的LADA患者胰岛β细胞功能的影响[J].中华内分泌代谢杂志,2004,20(6):564-567. 被引量:9
  • 2Nathan DM, Buse JB, Davidson BM, et al. Management of hyperglycaemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes[J]. Diabetologia, 2006, 49: 1711-1721.
  • 3Petersen JS, DiBona GE Acute sympathoinhibitory actions of metformin in spontaneously hypertensive rats[J]. Hypertension, 1996, 27: 619-625.
  • 4Campbell JD, Paul RJ. The nature of fuel provision for the Na^+, K+ ATPase in porcine vascular smooth muscle[J]. J Physiol, 1992, 447: 67-82.
  • 5Eurich DT, Tsuyuki RT, Majumdar SR, et al. Metfnrmin treatment in diabetes and heart failure: when academic equipoise meets clinical reallty[J]. Trials, 2009, 10: 12.
  • 6Khurana R, Malik IS. Metformin: safety in cardiac patients[J]. Heart, 2010, 96(2): 99-102.
  • 7Agard C, Rolli-Derkinderen M, Dumas-de-La-Roque E, et al. Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension[J]. Br J Pharmacol,2009,158(5):1285-1294.
  • 8DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care, 1992,15:318-368.
  • 9Lebovitz HE. Effects of oral antihyperglycemic agents in modifying macrovasular risk factors in type 2 diabetes. Diabetes Care, 1999, 22(Suppl 3):C41-C44.
  • 10Sindelar DK, Chu CA, Venson P, et al. Basal hepatic glucose production is regulated by the portal vein insulin concentration. Diabetes, 1998,47:523-529.

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