大管的化学成分研究

Chemical Constituents of the Plant Micromelum falcatum(Lour.) Tan.

从小芸木属植物大管茎皮部位共分离得到12个化合物,运用MS、1H NMR和13C NMR等波谱方法并结合文献对照分别鉴定为5-formyl-6,7-dimethoxycoumarin(1),isoscoploletin-β-D-glucoside(2),6-(trans-1-buten-3-only)-7-methoxycoumarin(3),6-羟基-7-甲氧基香豆素(4),microfalcatin isovalerate(5),小芸木宁(6),丁香苷(7),coniferin(8),methyl 2-O-β-D-glucopyranosylbenzoate(9),2-hydroxy-5-methoxy-trans-cinnamic acid(10),3,5-二甲氧基-4-羟基苯甲醛(11)和邻仲丁基苯酚(12)。其中化合物1为新的天然产物;除5和6外,其余化合物均首次从该植物中分离得到。

Twelve compounds were isolated from Micromelum falcatum and purified by repeated column chromatography on silica,Sephadex LH-20 gel,and HPLC and structurally identified by spectral analysis.The compounds were identified as 5-formyl-6,7-dimethoxycoumarin（1）,isoscoploletin-β-D-glucoside（2）,6-（trans-1-buten-3-only）-7-methoxycoumarin（3）,isoscopoletin-（6-hydroxyl-7-methoxyl coumarin,isoscopoletin）（4）,microfalcatin isovalerate（5）,micromelin（6）,syringin（7）,coniferin（8）,Methyl 2-O-β-D-glucopyranosylbenzoate（9）,2-hydroxy-5-methoxy-trans-cinnamic acid（10）,3,5-dimethoxyl-4-hydroxyl benzaldehyde（11） and o-sec-butyl phenol（12）.Compound 1 previously synthesized but first isolated as natural product,and the other compounds were isolated from this plant for the first time except 5 and 6.