辣椒辣素对大鼠急性切割痛的作用

The Effect of Capsaicin on Acute Cutting Pain in Rats

目的:研究辣椒辣素对足底切开大鼠疼痛相关行为的影响。方法:32只Wister雄性大鼠随机分为四组:生理盐水组、0.05%辣椒辣素组(C0.05)、0.1%辣椒辣素组(C0.1)、赋形剂组(吐温80),各200微升。切开前一天足底给药,分别测定给药前的基础值,给药后24小时,术后2小时及1、2、3天对热刺激的反应,并记录累积疼痛得分,术后三天进行组织病理学评估。结果:预先给予的辣椒辣素能够减弱热痛觉过敏和降低累积疼痛得分。组织病理学检查证实:与生理盐水比较辣椒辣素影响切口的恢复。结论:辣椒辣素预处理具有预防术后痛的作用。对切口组织学的影响可能与药物抑制疼痛行为有关,而不一定是药物的局部作用。

Objective： To investigate the effect of capsaicin on pain-related behavior after plantar incision in rats. Methods： 32 Wister male rats were randomly divided into four groups： the saline group, 0.05% capsaicin （C0.05）group, 0.1% capsaicin （C0. 1）group, excipient （Tween 80） group, 200 uL respectively. Administered the day before the plantar incision,determined the response to thermal stimulation at before administration and 24 hours after administration, postoperative 2 h and 1, 2, 3 days, respectively. Recorded the cumulative pain score and evaluated histopathology after three days. Results： Capsaicin pre-given can reduce thermal hyperalgesia and reduced the cumulative pain score. Histopathological examination confirmed that Capsaicin affect the recovery of the incision compared with saline. Conclusion： Capsaicin had postoperative analgesia after plantar incision, the effect on histological was likely related to its inhibitory effects on pain behaviors and was not necessarily a local effect of the drug.