摘要
目的:研究虫草菌丝在大鼠肝硬化中对TGF-β1和VEGF的影响,探讨虫草菌丝在大鼠肝硬化治疗中的作用机制。方法:取健康成年雄性SD大鼠60只,随机分为3组:正常组(A组)、急性CCL4肝硬化模型组(B组),虫草菌丝组(C组),12周后比较分析3组TGF-β1和VEGF表达。结果:治疗后,C组TGF-β1、VEGF和B组比较有统计学意义,(P<0.05)。结论:虫草菌丝在大鼠肝硬化治疗中具有明显的效果,可能与抑制TGF-β1和VEGF表达有关。
Objective： To investigate the effect of cordyceps sinensis berk. sacc on expression of TGF- β1 and VEGF in liver fiberosis. Methods： Sixty male adult SD rats were randomly divided into three groups （n=20 each）, control group （A group）, acute CCL4hepatic injury model group （B group）, cordyceps sinensis berk. sacc group （C group）The expression of TGF-β 1 and VEGF were evaluated after 12weeks. Results： After treatment, the expression of TGF-β1 and VEGF orB group was higer significantly difference with C group, （P〈0.05）. Conclusion： Cordyceps sinensis berk. sacc may alleviate liver fiberosis in rats, it was possibly through decreasing the expression of TGF-β1 and VEGF.
出处
《现代生物医学进展》
CAS
2012年第27期5248-5250,共3页
Progress in Modern Biomedicine
