老年急性脑梗塞患者血清TNF-α和IL-6水平的变化及其临床意义

The Serum TNF-α and IL-6 Level Changes and its Clinical Significance in the Elderly Patients with Acute Cerebral Infarction

目的:观察老年急性脑梗塞(ACI)患者血清TNF-α和IL-6水平的变化并探讨其临床意义。方法:选择老年ACI患者53例,观察以上入选患者入院后第7d、第9d和第11d血清TNF-α和IL-6水平的变化,并与26例健康人对照;同时分析53例老年ACI患者血清TNF-α和IL-6水平与患者脑梗塞面积及神经功能缺损评分的Spearman等级相关性。结果:老年ACI患者血清TNF-α和IL-6水平显著高于健康人(P<0.01);随着治疗的进展与病情的稳定及恢复,患者血清TNF-α和IL-6水平随之显著下降(P<0.05);同时患者血清TNF-α和IL-6水平与病变的严重程度呈正相关性(P<0.05);治疗11d后血清TNF-α和IL-6降低量与病变的严重程度呈正相关性(P<0.05)。结论:在老年ACI患者治疗过程中,应进行血清TNF-α和IL-6水平的动态监测,可提示病变的发生发展并指导临床治疗。

Objective： To observe the serum TNF-a and IL-6 level changes and discuss its clinical significance in the elderly patients with acute cerebral infarction. Methods： Collect 53 elderly patients with acute cerebral infarction, observe the serum TNF-a and IL-6 level changes the 7th day, the 9th day and the 1 lth day after admission and compare with 26 healthy people;analysis the correlation analysis of serum TNF-a and IL-6 levels with disease severity. Results： The elderly patients＇ TNF-a and IL-6 level were statistical higher than the healthy people＇s（P〈0.01）; the serum TNF-a and IL-6 levels significantly decreased （P 〈0.05） with the progress of treatment;the aerum TNF-a and IL-6 levels were positively correlated （P 〈0.05） with the disease severity, the aerum TNF-a and IL-6 levels＇ reduction were positively correlated （P 〈0.05） with the disease severity after 1 ldays＇ treatment. Conclusion： In the course of treating elderly patients with ACI,we should dynamic monitor the serum TNF-a and IL-6 levels,it could prompt the development of the lesions and guide the clinical treatment.