64例结肠黑变病回顾性分析

A Retrospective Analysis of 64 Patients with Melanosis Coli

目的:探讨分析结肠黑变病(melanosis coli,MC)的致病因素、预后及其与结肠癌、结肠息肉等疾病的关系。方法:回顾性分析由电子结肠镜检出的64例MC患者的临床资料、内镜表现及病理结果。结果:64例患者中47例有便秘,服用葸醌类泻药史者54例。诊断为MCI°24例(37.5%),MCⅡ°28例(43.8%),MCⅢ°12例(18.7%)。合并有结肠息肉14例、痔疮9例、溃疡性结肠炎2例、结肠癌1例。结论:服用泻药、便秘以及相关细胞凋亡是导致MC发生的重要因素。泻剂主要为蒽醌类,MC的发病率与性别不存在相关性,其与结肠癌、结肠息肉和溃疡性结肠炎等的关系需要进一步深入研究,应积极给予早期诊断和治疗。

Objective： To investigate and analyze the causal factors and prognosis ofmelanosis coli （MC）, and its correlation with colon cancer, colon polyp and other diseases. Methods： Clinical data, endoscopic manifestation and pathologic results of 64 subjects with MC was retrospectively analyzed. Results： Among the 64 MC patients, 47 patients have constipation, 54 patients have used laxative anthraquinone. 24 patients were diagnosed as MCI0 （37.5 %）, 28 diagnosed as MC II ° （43.8 %）and 12 diagnosed as MC III° （18.7 % ）. 14 patients were complicated with colon polyp, 9 with piles, 2 with ulcerative colitis, 1 with colon cancer. Conclusion： Laxative usage （mainly anthraquinone）, constipation and related cell apoptosis are important factors leading to MC. No correlation existed between the incidence of MC and gender. More efforts are needed to clarify its relationship with colon cancer, polyp and ulcerative colitis, and early diagnosis and treatment are necessary.