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与阿尔兹海默症相关的G蛋白偶联受体研究进展 被引量：8

Advancement of G Protein-coupled Receptors Related to Alzheimer's Disease
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摘要 G蛋白偶联受体(GPCRs)在大脑信号传递中至关重要,而在阿尔兹海默症(AD)中,G蛋白偶联受体通过调控α-、β-及γ-分泌酶分泌、淀粉样前体蛋白(APP)生成及β-淀粉样蛋白(Aβ)降解,直接影响β-淀粉样蛋白在神经系统信号级联反应;另外,阿尔兹海默症中β-淀粉样蛋白的生成可以扰乱G蛋白偶联受体功能。因此,阐明G蛋白偶联受体与阿尔兹海默症发病之间的关联有助于开发以G蛋白偶联受体为靶点的阿尔兹海默症治疗药物。 G protein-coupled receptors （GPCRs） play a crucial role in patients with Alzheimer＇s disease （AD）. GPCRs regulate the levels of a-secretase, β-secretase and y-secretase, the synthesis of amyloid precursor protein （APP）, the degradation of amyloid- β （Aβ）, influencing the amyloid cascade. Besides, Aβ could disturb the function of GPCRs. Therefore, elucidation the relationship between GPCRs and.AD associated with Aβ in the pathogenesis contributed to the development of novel drugs targeted GPCRs in AD treatment.
作者 刘小阳 韩玉娇 宋超 何玲
机构地区 中国药科大学药理学教研室
出处 《现代生物医学进展》 CAS 2012年第27期5380-5384,共5页 Progress in Modern Biomedicine
基金 国家"十二五"重大新药创制专项"新型G蛋白偶联受体靶向药物筛选体系建立及其关键技术研究"(No.2012ZX09504001-001) 2010年教育部"新世纪优秀人才支持计划资助(No.NCET-10-0817) 国家基础科学人才培养基金(No.J0630858)
关键词 G蛋白偶联受体 Β-淀粉样蛋白 阿尔兹海默症 G protein-coupled receptors Amyloid-β Alzheimer＇s disease
分类号 R741.02 [医药卫生—神经病学与精神病学]
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参考文献31

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同被引文献64

  • 1陈立朝,许民辉,周继红.CRH通过PKA途径调节大鼠下丘脑CRH表达的研究[J].第三军医大学学报,2004,26(16):1459-1462. 被引量：3
  • 2陈立朝,许民辉,周继红.PKA信号通路调控大鼠下丘脑脑片CRHmRNA的表达研究[J].中华神经外科疾病研究杂志,2005,4(2):141-144. 被引量：1
  • 3金丹,沙金燕.促肾上腺皮质激素释放激素受体的研究进展[J].中国妇幼健康研究,2006,17(3):244-248. 被引量：3
  • 4曾纯,严灿,徐志伟,吴丽丽.促肾上腺皮质激素释放激素受体在应激反应中的作用研究[J].中国药理学通报,2006,22(5):517-520. 被引量：8
  • 5Eugenio Barone,Fabio Di Domenico,Cesare Mancuso,D. Allan Butterfield.The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It’s time for reconciliation[J].Neurobiology of Disease.2014
  • 6Eugenio Barone,Fabio Di Domenico,Rukhsana Sultana,Raffaella Coccia,Cesare Mancuso,Marzia Perluigi,D. Allan Butterfield.Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment[J].Free Radical Biology and Medicine (-).2012(11-12)
  • 7Fabio Di Domenico,Eugenio Barone,Cesare Mancuso,Marzia Perluigi,Annalisa Cocciolo,Patrizia Mecocci,D. Allan Butterfield,Raffaella Coccia.HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer’s Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease[J].Journal of Alzheimer’s Disease.2012(2)
  • 8D. Allan Butterfield,Eugenio Barone,Fabio Di Domenico,Giovanna Cenini,Rukhsana Sultana,Michael P. Murphy,Cesare Mancuso,Elizabeth Head.Atorvastatin treatment in a dog preclinical model of Alzheimer’s disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain[J].The International Journal of Neuropsychopharmacology.2011(7)
  • 9Moller C,Hafkemeijer A,Pijnenburg Y A,et al.Joint assessment of white matter integrity,cortical and subcortical atrophy to distinguish AD from behavioral variant FTD:A two-center study[J].Neuroimage Clin,2015(9):418-429.
  • 10Murray P S,Kirkwood C M,Gray M C,et al.betaAmyloid 42/40ratio and kalirin expression in Alzheimer disease with psychosis[J].Neurobiol Aging,2012,33(12):2807-2816.

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现代生物医学进展
2012年 第27期

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