不同疾病血浆内毒素含量的测定及结果分析

Plasma endotoxin detection in different diseases and results analysis

目的探讨不同疾病患者血浆内毒素的含量及内毒素检测的临床意义。方法用鲎试剂定量动态比浊法检测患者和健康对照者血浆内毒素含量。结果 30例健康对照组血浆内毒素含量为(3.20±1.71)pg/mL;51例肝硬化患者内毒素阳性率为49.02%,平均内毒素含量为(74.97±184.99)pg/mL;31例发热、28例白血病、16例肺炎、12例肺癌、9例肝炎和14例肝癌患者组血浆内毒素阳性率分别为67.74%、67.86%、68.75%、100%、33.33%、57.14%,内毒素平均值分别为(73.47±152.83)、(29.47±35.41)、(239.45±662.30)、(259.42±303.62)、(8.74±10.11)、(17.33±18.24)pg/mL,与健康对照组相比差异均有统计学意义。不同肝病之间内毒素含量比较差异无统计学意义。结论检测血浆内毒素含量有助于早期判断感染类型及是否存在内毒素血症,有利于临床及早诊治疾病。

Objective To study the clinical significance of plasma endotoxin level and its detection in different diseases.Methods Plasma endotoxin in the patients and healthy people were detected by the turbidimetric assay with limulus reagents.Results The plasma endotoxin levels in 30 healthy people as the control group was（3.20±1.71）pg/mL.Mean plasma endotoxin level in 51 cases of hepatocirrhosis was（74.97±184.99） pg/mL and its positive rate was 49.02%.Mean plasma endotoxin levels in 31 cases of fever,28 cases of leucocythemia,16 cases of pneumonia,12 cases of lung cancer,9 cases hepatitis and 14 cases of liver cancer were（73.47±152.83）,（29.47±35.41）,（239.45±662.30）,（259.42±303.62）,（8.74±10.11） and（17.33±18.24）pg/mL,respectively.The positive rates of above-mentioned different groups were 67.74%,67.86%,68.75%,100%,33.33% and 57.14%,respectively.All patients groups showed statistical difference compared with the healthy people group.But there was no statistical difference among different liver diseases.Conclusion Plasma endotoxin detection is conducive to estimate the infection types and whether endotoxemia exists,and also help doctors to make early diagnosis and early treatment.