雷贝拉唑和奥美拉唑治疗消化性溃疡疗效比较

Effect comparison of rabeprazole and omeprazole in the treatment of peptic ulcer

目的比较观察雷贝拉唑与奥美拉唑治疗消化性溃疡的临床效果。方法将84例消化性溃疡患者随机分成A、B组各42例。A组给予雷贝拉唑10mg,每天1次晨服;B组给予奥美拉唑20mg,每天1次晨服。2组均连服7d。治疗后比较2组上腹疼痛、泛酸改善情况,记录患者有无不良反应发生。结果 A组腹痛、泛酸改善情况优于B组,差异有统计学意义(P<0.05或P<0.01)。2组均未发生明显不良反应。结论雷贝拉唑与奥美拉唑治疗消化性溃疡均安全有效,但雷贝拉唑治疗效果优于奥美拉唑,值得临床推广应用。

Objective To compare the clinical effect of rabeprazole and omeprazole in the treatment of peptic ulcer. Methods 84 cases patients with peptic ulcer were randomly divided into A group and B group, each of 42 cases. A group was given with rabeprazole 10mg, 1 times daily morning dress;B group was given with omeprazole 20mg, 1 times a day, morning suits. Two groups were both served 7d. After treatment, compared the improvement of epigastric pain and acid reflux, then recorded the adverse reactions situation of two groups. Results The improvement of epigastric pain and acid reflux in A group was better than those in group B, the difference was statistically significant （P 〈 0.05 or P 〈 0.01 ）. No significant adverse reactions occurred in two groups. Conclusion Both babeprazole and omeprazole are safe and effective for the treatment of peptic ulcer, but rabeprazole is better than omeprazole,is worthy of clinical application.