肾癌术后应用α-干扰素的疗效观察

Efficacy analysis of α-interferon in the treatment of renal cell carcinoma after nephrectomy

目的观察肾癌术后应用α-干扰素(α-IFN)的治疗效果。方法肾癌患者102例随机分为治疗组52例和对照组50例。治疗组肾癌切除术后应用α-IFN治疗,对照组单纯行肾癌切除术治疗。比较2组治疗效果。结果 2组早期(Robson分期Ⅰ～Ⅱ期)肾癌患者5年生存率差异无统计学意义(P>0.05);治疗组晚期(Ⅲ期)肾癌患者5年生存率明显高于对照组,差异有统计学意义(P<0.05)。结论晚期(Ⅲ期)肾癌切除术后应用α-IFN治疗能延长患者生存期,提高长期生存率,值得临床推广应用。

Objective To observe the effect of or-interferon（a-IFN） in the treatment of renal cell carcinoma after nephrectomy. Methods 102 cases patients with renal cell carcinoma were randomly divided into therapeutic group （52 cases ） and control group（50 cases）. Terapeutic group treated by ct-IFN after nephrectomy ,control group treated with nephrectomy alone. Compared the effect of two groups. Results The difference of the 5-year survival of（ Robson stage I - II ） between two group was no statistical significance（ P 〉 0.05 ） ;The 5-year survival rates in treatment group（ stage III ） was significantly higher than that in control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusion The application of a-IFN in III period renal cell carcinoma after nephreetomy can prolong survival and improve long-term survival, worthy of clinical application.