三七通舒胶囊对慢性脑血管功能不全患者脑血流储备功能的影响

Effect of San-qi-tong-shu Capsule on Chronic Cerebral Circulation Insufficiency and Cerebral Vascular Reserve Capacity

目的:观察三七通舒胶囊治疗慢性脑血管功能不全(CCVI)的临床疗效及其对脑血流储备功能的影响。方法:用TCD屏气实验测定了临床确诊的142 CCVI患者及140例健康体检者的屏气指数(BHI)。并将CCVI患者随机分为对照组(68例)和治疗组(74例),对照组口服曲克芦丁,治疗组口服三七通舒胶囊,疗程为4 W,治疗结束复查TCD屏气实验,观察两组临床症状疗效及脑血流储备功能的变化。结果:CCVI患者BHI(0.81+0.21)显著低于健康体检者(1.12+0.27,P<0.01),治疗组治疗后BHI(0.95+0.19)明显高于治疗前(0.82+0.20,P<0.01),对照组治疗后BHI(0.83+0.20)与治疗前(0.81+0.19)比较差异无显著性(P>0.05)。治疗组临床症状总有效率为80.88%,显著优于对照组的48.65%(P<0.05)。结论:三七通舒胶囊治疗慢性脑血管功能不全疗效确切,能明显改善CCVI患者的脑血流储备功能。

Objective： To observe the effect of San-qi-tong-shu capsule on chronic cerebral vascular insufficiency （CCVI） and the change of its cerebral vascular reserve capacity. Methods： The breath holding index （BHI） of 142 patients with CCVI and 140 healthy were observed by TCD Breath holding test. Patiefnts with CCVI were randomly divided into two groups ： treatment group （ n = 68） and control group （ n = 74） . Patients in treatment group were treated by San-qi-tong-shu capsule ; patients in control group were treated by Troxerutin. The course was 30 days in two groups. BHI were observed before and after treatment. Results： There were high significant differences between patients with CCVI （0. 81 ＋0. 21 ） and healthy （0. 82 ＋0.20, P 〈0. 01 ） BHI. There were high signif- icant differences between before treatment （0. 82 ＋0. 20） and after treatment （0. 95 ＋0. 19, P 〈0. 01 ） in treatment group, But no significant differences between before treatment （0. 81 ＋0. 19） and after treatment （0. 83 ＋0. 20, P 〉0. 05 ） in control group. The accumulated effective rate of treatment group （80. 88% ） was significant higher than control group （48. 65%, P 〈0.05） . Conclu- sion： Sanqi-Tongshu capsule have definite effect for relieve clinical symptoms and improve cerebral vascular reserve capacity in CCVI patients.