斑点追踪成像评价2型糖尿病患者左心室收缩功能的早期改变

Evaluation of left ventricular systolic dysfunction in patients with type 2 diabetes mellitus by speckle tracking imaging

目的:探讨斑点追踪成像(STI)技术评价2型糖尿病(T2DM)患者左心室收缩功能的早期改变。方法:选取77例LVEF正常的T2DM患者,依据有无合并高血压分为单纯糖尿病组(DM组)39例,糖尿病合并高血压组(DH组)38例,正常对照组(NC组)34例,应用STI技术测量左心室长轴切面的纵向收缩期峰值应变(SLs)、短轴切面的圆周(SCs)及径向收缩期峰值应变(SRs)。结果:左心室整体SLs在两病例组显著降低(P<0.01),其中DH组降低更加显著(P<0.01);左心室整体SCs及SRs仅在DH组显著降低(P<0.01)。结论:无心力衰竭症状LVEF正常的T2DM患者的左心室收缩功能已降低。

Objective： To assess the early changes of left ventricular （LV） systolic function in patients with type 2 diabetes meUitus （T2DM） by speckle tracking imaging （STI）. Methods： Seventy-seven T2DM patients with normal left ventricular ejection fraction （LVEF） were divided into 2 groups according to their blood pressure ： T2DM isolated group （ DM group, n = 39） and T2DM associated with hypertension group （ DH group, n = 38 ）. Thirty-four healthy individuals were enrolled as normal control （NC） group. Standard two dimensional images were acquired from the LV apical and short-axis views. LV systolic peak longitudinal strain （SLs）, systolic peak circum- ferential strait/ （SCs） and systolic peak radial strain （SRs） were measured by STI. Results： The average SLs of global LV was significantly lower in both DM and DH groups than that in control group （ P 〈 0. 01 ）, while it was significantly more prominent in DH group （P 〈 0. 01 ）. The average SCs and SRs of global LV were only significantly reduced in DH group （P 〈 0. 01 ）. Conclusion： Left ventricular systolic function had significantly impaired in T2DM patients with normal LVEF without symptomatic heart failure.