生脉注射液中高异黄酮类成分研究

Study on Homoisoflavones in Shengmai Injection

目的探讨生脉注射液中高异黄酮类成分物质基础。方法以麦冬萃取物化学成分研究为基础,采用液相色谱-质谱联用技术对8家生产企业的生脉注射液样品进行化学成分指认。结果麦冬萃取物中8个主要化学成分中8家生产企业多数共有成分为麦冬黄酮B,麦冬黄烷酮B,麦冬黄烷酮A,甲基麦冬黄烷酮A,甲基麦冬黄烷酮B。结论建立了生脉注射液中高异黄酮类成分的检查方法,为研究注射剂高异黄酮类成分及统一制法提供实验依据。

OBJECTIVE To investigate the composition of homoisoflavones in Shengmai injection. METHODS On the basis of studies on the chemical constituents of Ophiopogonis Radix extract, the chemical constituents in Shengmai injection from eight enterpri- ses were identified by LC-MS. RESULTS Ophiopogonone B, ophiopogonanone B, ophiopogonanone A, methylophiopogonanone A, and methylophiopogonanone B were the common components among the eight identified constituents in Ophiopogonis Radix extract. CONCLUSION The analytical method for homoisoflavones in Shengmai injection is established, which can be used as the basis for further study and quality control.