摘要
目的对改性透明质酸制备的载药薄膜进行体外药物释放研究,为制备良好的缓释制剂提供参考依据。方法用网碟法及紫外分光光度法测定载药薄膜的药物体外释放度,考查了改性剂用量和药物溶解性对释放度的影响。结果载药薄膜对非水溶性药物具有较好的缓释作用,药物的体外释放符合Higuchi公式,受扩散机制控制。增加改性剂的用量可以降低药物的释放速率。结论改性透明质酸薄膜对疏水性药物具有较好的缓释作用,是一种良好的药物载体。
OBJECTIVE To evaluate the in vitro drug release properties of modified hyaluronic acid films. METHODS The drug release rates of the films were measured by dictyo-dish method and UV-Vis absorption spectroscopy. The effects of modifier con- tents and the solubility of medicines on the release were investigated. RESULTS The release of some hydrophobic drugs from the films were sustained. The drug release pattern followed Higuchi equation, and was controlled by diffusion mechanism. Drug release rates were delayed by increasing contents of modifier. CONCLUSION The films made of modified hyaluronic acid have excellent po- tentials as carriers for the sustained release of some hydrophobic drugs.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2012年第19期1558-1560,共3页
Chinese Pharmaceutical Journal
关键词
改性透明质酸
溶胀薄膜
药物缓释
modified hyaluronic acid
swelling film
drug sustained release
