意识与脑功能连接性：麻醉药物作用机制的研究进展

Consciousness and brain functional connectivity： the advance in mechanisms of general anesthetics

背景功能连接性（整合），相对于解剖结构连接性，是指在耦联的神经系统中信号之间存在统计学上的依赖关系，近年来发现大脑不同区域之间的功能连接性与意识关系密切，而麻醉药物诱导意识丧失的机制很可能与功能连接性有关。目的现从意识与大脑功能连接性角度对麻醉药物作用机制的研究进展作一综述。内容静息态功能磁共振（resting state functional magnetic resonance imaging，rs-fMRI）在分析大脑功能连接性方面具有优势，多项研究应用rs捌RI技术分析全身麻醉药物对脑区功能连接性的影响，提示麻醉药物的可能作用靶点为脑区功能连接性。趋向rs-fMRI技术的不断发展，为研究麻醉药物作用机制开辟了新的方向。

Background Brain functional connectivity, also called integration, refers to the existence of statistical dependencies between signals in the uncoupling nervous system, which is relative to the anatomical connectivity. Recently, it is found that the functional connectivity between different regions of the brain is closely associated with the consciousness. And the mechanisms of anesthetic drug-induced loss of consciousness may be related to functional connectivity. Objective Review the advance in the mechanisms of general anesthetics, from the perspective of the relationship of brain functional connectivity and consciousness. Content Resting state functional magnetic resonance imaging （rs-fMRI） has great advantages in the analysis of brain functional connectivity. Studies of the effect of general anesthetics on functional connectivity of different brain regions using rs- fMRI suggested that one of the possible action targets of anesthetics is the brain functional connectivity. Trend The development of rs-fMRI technology offers a new insight into the exploration of the mechanisms of anesthetics.