期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

细小病毒非结构蛋白NS1作用机制的研究进展 被引量：5

Advances in Functional Mechanism of Parvovirus Non-structural Protein NS1
下载PDF
导出
摘要 细小病毒编码的非结构蛋白NS1(non-structural protein 1)是一种多功能蛋白,该蛋白质与病毒DNA的复制、基因转录调控、诱导细胞病理变化等密切相关。本文对细小病毒NS1蛋白的基因转录激活功能、磷酸化修饰以及与胞内蛋白的相互作用等研究进展进行综述,为研究家蚕双义病毒(BmBDV)的NS1蛋白作用机制提供参考。 The non-structural protein NS1 encoded by parvovirus is a multi-functional protein, and is considered to have a close relationship with viral replication, regulation of gene transcription, induction of cytopathol0gical alteration etc. In this review, research progress in transcriptional activation activity, phosphorylation modification, and intracellular protein interaction of parvovirus protein NS1 was summarized, providing references for studies on functional mechanism of pro- tein NS1 from Bombyx mori bidensovirus （BmBDV）.
作者 李国辉 胡朝阳 唐琦 王鹏
机构地区 江苏大学生命科学研究院
出处 《蚕业科学》 CAS CSCD 北大核心 2012年第5期919-923,共5页 ACTA SERICOLOGICA SINICA
基金 国家自然科学基金项目(No.31000080) 江苏大学高级人才启动基金项目(No.09JDG057)
关键词 细小病毒 非结构蛋白 NS1蛋白 转录激活 磷酸化修饰 蛋白质互作 Parvovirus Non-structural protein Protein NSI Transcriptional activation Phosphorylation modification Protein-protein interaction
分类号 S852.65 [农业科学—基础兽医学]
  • 相关文献

参考文献31

  • 1Christensen J, Cotmore S F,Tattersall P. Minute virus of mice tran- scriptional activator protein NS1 binds directly to the transactiva- tion region of the viral P38 promoter in a strictly ATP-dependent manner [J].J Virol, 1995,69 (9) :5422 - 5430.
  • 2Jindal I-I K,Yong C B,Wilson G M,et al. Mutations in the NTP- binding motif of minute virus of mice ( MVM ) NS-I protein un- couple ATPase and DNA helicase functions [ J ]. J Biol Chem, 1994,269 ( 5 ) :3283 - 3289.
  • 3Lachmann S, Rommeleare J, Nuesch J P. Novel PKC'q is required to activate replicative functions of the major nonstruetural protein NS1 of minute virus of mice[J]. J Virol,2003,77(14) :8048 - 8060.
  • 4Yang B, Zhang J M, Cai D W, et al. Biochemical characterization ofPeriplanetafuliginosa densovirus non-structural protein NS1 [ J ]. Bioehem Biophys Res Commun ,2006,342 ( 4 ) : 1188 - 1196.
  • 5Naesch J P F, Rommelaere J. A viral adaptor protein modulating casein kinaseⅡactivity induces cytopathic effects in permissive ceils[ J ]. Proc Natl Acad Sei USA, 2007,104 ( 30 ) : 12482 - 12487.
  • 6Daettler L, H6rlein R, Rommelaere J, et al. Modulation of minute virus of mice eytotoxie activities through site-directed mutagenesis within the NS coding region [ J ]. J Virol, 2003,77 (23):12466 - 12478.
  • 7Christensen J, Tattersall P. Parvovirus initiator protein NS1 and RPA coordinate replication fork progression in a reconstituted DNA replication system [ J ]. J Virol,2002,76 ( 13 ) :6518 - 6531.
  • 8Tijssen P, Li Y, El-Far M, et al. Organization and expression strate- gy of the ambisense genome of densonucleosis virus of Galleria mel- lonella [ J ]. J Viro1,2003,77 (19) : 1035"/- 10365.
  • 9Fediere G, El-Far M, Li Y, et al. Expression strategy of densonucle- osis virus from Mythimna/orey/[ J ]. Virology ,2004,320( 1 ) :181 - 189.
  • 10Baquerizo-Audiot E, Abd-Alla A, Jousset F, et al. Structure and ex- pression strategy of the genome of Culex pipiens densovirus, a mos- quito densovirus with an ambisense organization[ J]. J Viro1,2009, 83(13) :6863 -6873.

同被引文献41

引证文献5

二级引证文献21

蚕业科学
2012年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部