蜘蛛香对高脂血症大鼠血脂及肝功能的影响

Effect of the Extract of Valeriana jatamansi on the Blood Lipid and Liver Function in Experimental Hyperlipidemia Rats

目的:探讨蜘蛛香对高脂血症大鼠血脂及肝功能的影响。方法:清洁级SD大鼠,除正常组外,其余各组采用高脂饲料喂养25 d建立高脂血症大鼠模型后,洛伐他汀组按3 mg.kg-1每日ig给予一次洛伐他汀溶液,蜘蛛香醇提物低、中、高3个剂量组每日分别按相当于生药1.25,2.5,5 g.kg-1ig给药1次,造模各组仍喂食高脂饲料。2周后,检测血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)及肝组织TC,TG。结果:高脂饲料诱导后,模型对照组大鼠血清及肝组织中TC,TG,LDL-C较空白对照组显著升高(P<0.05,P<0.01),且血清ALT,AST也显著升高(P<0.05)。洛伐他汀,蜘蛛香醇提物给药后,均能显示显著降低血清及肝组织的TG,肝组织中TC及血清中ALT,AST的作用(P<0.01)。结论:蜘蛛香能降低实验性高脂血症大鼠血脂,并能保护高血脂动物的肝功能。

Objective：To observe the effect of the extract of Valeriana jatamansi Jones on the blood lipid and liver function in experimental hyperlipidemia rats.Method：All the rats,except for the normal group,were fed with high-fat diets for 25 days to establish hyperlipidemia model.Then lovastatin group was given lovastatin at the doses of 3 mg · kg-1 once a day,and V.jatamansi high,medium,and low group were respectively given the alcohol extract of V.jatamansi at the doses of 1.25,2.5,5 g · kg-1 equivalently to the crude V.jatamansi by intragastric administration once a day.After administration,every group was still fed with high-fat diets.Two weeks later,the serum level of total cholesterol（TC）,triglycerides（TG）,lipoproten cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST） and liver TC,TG was detected.Result： the TC,TG,LDL-C levels in the serums and livers in model rats were higher than these in normal rats（P0.05,P0.01）,and the serum levels of ALT and AST also increased significantly（P0.05）.Both lovastatin and the alcohol extract of V.jatamansi showed significantly decreased TG level in serum and liver（P0.01）,the TC level in liver（P0.01）and the ALT and AST in serum（P0.01）.Conclusion： V.jatamansi can regulate blood lipids level,and protect liver in hyperlipidemia rats.