摘要
介绍了近年来脑靶向制剂的研究现状,为新型中药脑靶向制剂的研究和开发提供参考。通过查阅国内外相关文献资料并进行分析、归纳和总结,解释了血脑屏障的生理结构特点,介绍了常用的促进药物透过血脑屏障的方法;通过了解脑靶向制剂的给药方式及新剂型研究(β-环糊精包合物、前体药物、脂质体、纳米粒、微乳、原位凝胶),阐述了中药经鼻腔给药发挥中枢治疗作用的优势和可行性,认为中药在脑靶向给药方面必将有更加广阔的应用前景。
Process on drug delivery for brain targeting was summarized to provide basis for traditional Chinese mediline（TCM）.Literatures about the development of brain-targeted preparation in recent years were reviewed and analyzed.This paper not only described the physiological structure characteristics of blood-brain-barrier,but also introduced some common methods for promoting drugs through the blood-brain-barrier.The paper also described the administration methods and new preparations（β-CD,prodrug,liposomes,nanoparticles,micro emulsion,in situ gel）to understand the advantages and feasibility of traditional Chinese medicine（TCM） nasal administration.Brain-targeted preparations of TCM had wide development prospect.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第19期307-310,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
"重大新药创制"专项(2009ZX09502008)
国家自然科学基金项目(81073057
81102816)
教育部博士点基金(20090013110007)
北京中医药大学创新团队项目(2011-CXTD-13)
关键词
血脑屏障
脑靶向制剂
给药方式
新剂型
blood-brain-barrier
brain-targeted preparation
administration methods
new preparations
