中风病急性期“毒损脑络”特征症状与实验室指标相关性研究

Research of correlation of characteristic symptoms and indexes of ＂brain collateral damage＂ at acute stage of stroke

目的探讨中风病急性期“毒损脑络”特征症状与实验室指标的相关性，以期寻找症状与指标间的变化规律。方法确诊为中风病急性期的患者70例，分两个时点进行观测。观察反应“毒损脑络”的特征症状与从不同角度选择的6个实验室指标的相关性。结果非特异性症状出现个数与高敏C反应蛋白（Hs．CRP）、白细胞介素-6（IL-6）、氧化低密度脂蛋白（OX-LDL）、神经元特异性烯醇化酶（NSE）有关联和联动性。发病14d，非特异性症状个数与Hs-CRP、IL-6、OX-LDL、NSE的相关系数分别是0．307、0．289、0．342、0．253（P〈0．05）。非特异性症状出现1-3个组，共40例，与OX-LDL（32．37±31．17）μg／l、NSE（2．82±1．25）ng／ml、基质金属蛋白酶．9（MMP-9，214．97±137．88）ng／ml具有明显相关性（P均〈0．05）。嗜睡与Hs-CRP（R=0-318、P=0．016）、表情呆滞或反应迟钝与IL-6（R=0．384、P=0．006）有相关性。结论“毒损脑络”时的嗜睡、表情呆滞或反应迟钝与Hs-CRP、IL-6、OX-LDL、NSE在不同角度、不同层次有相关和联动性。

Objective To explore the correlation of characteristic symptoms and indexes of ＂brain collateral damage＂ at acute stage of stroke. Methods Seventy cases who got stroke within 72 hours were included. Five nonspecific symptoms and 6 indexes were observed at two time points. Results There were positive correlations between the number of nonspecific symptoms and the value of Hs-CRP, IL-6, OX-LDL, NSE. The correlation coefficients were 0.307, 0.289, 0.342, 0.253 and P〈0.05. Nonspecific symptoms appeared in l to 3 groups, altogether 40 cases were involved, and the groups had significant deviation compared with the group without nonspccific symptoms on OX-LDL （32.37 ± 31.17） μg/l, NSE （2.82±1.25） ng/ml, MMP-9 （214.97 ± 137.88） ng/ml and P〈0.05. Single symptom especially dull expression and hypersomnia were proved to be related with the indexes. For example, the correlation coefficient was 0.318 between hypersomnia and Hs-CRP. The correlation coefficient was 0.384 between dull expression and IL-6. Conclusion Characteristic symptoms were well correlated and ganged with the indexes from different view or level. It acted as representative combination of ＂brain collateral damage＂ syndrome.