升清降浊汤为主对代谢综合征患者血压、血脂及糖化血红蛋白的疗效观察

Shengqing-Jiangzhuo decoction with western conventional therapy on blood pressure, lipids and glyeated hemoglobin in patients with metabolic syndrome

目的观察自拟升清降浊汤配合西医常规治疗代谢综合征的临床疗效。方法将2008年3月至2011年7月高密市人民医院中医科120例代谢综合征患者，按病例尾号随机分为两组各60例，对照组给予西药个体化及对症治疗，治疗组在对照组治疗基础上口服自拟升清降浊汤，两组均连续治疗2个月。观察两组患者治疗前后主要症状的临床疗效以及血压、体重指数（BMI）、腰臀围比（WHR）血脂水平、糖化血红蛋白（HbA1C）的变化。结果①临床疗效：治疗后，两组患者头晕、口干、便秘、腹胀、急躁易怒等症状改善，治疗组总有效率为85．00％，对照组为73．33％，治疗组总有效率优于对照组（P=0．045）；②实验室指标检测：治疗后治疗组收缩压（127．30±8．00）mmHg、舒张压（81．35±3．81）mmHg、体重指数（23．3±1．48）、腰臀围比（0．85±0．07）、以及胆固醇（3．32±0．81）mmol／L、甘油三脂（1．76±1．01）mmol／L、低密度脂蛋白胆固醇（2．20±O．72）mmol／L、高密度脂蛋白胆固醇（1．39±0．14）mmol／L、糖化血红蛋白（6．58±0．82）mg／d1与对照组比较，差异均有统计学意义（P〈0．05或P〈0．01）。结论升清降浊汤配合常规治疗代谢综合征可提高临床疗效。

Objective To observe the effects of Shengqing-Jiangzhuo decoction combined with western medicine on metabolic syndrome. Methods 120 patients with metabolic syndrome in Gaomi City People＇s Hospital of Traditional Chinese Medicine from March 2008 to July 2011 were randomly divided into a treatment group and a control group according to case number, with 60 cases in each group. The control group was treated with Western medicine individualized and symptomatic treatment, while on the basis of the control group the treatment group was additionally treated with Shengqing-Jiangzhuo decoction. Both groups were continuously treated for 2 months. The main symptoms of the two groups of patients before and after clinical efficacy as well as blood pressure, body mass index （BMI）, waist-hip ratio （WHR） lipid levels, glycosylated hemoglobin （HbA1C） changes were observed. Results （1） The clinical efficacy： After treatment, dizziness, dry mouth, constipation, bloating, irritability and other symptoms improved significantly, with 85.00% and 73.33% of the total effective rate in treatment group and control group respectively; （2） laboratory parameters detection： there was statistical difference between the control group and the treatment group in terms of systolic blood pressure （ 127.30 ± 8.00） mm Hg, diastolic blood pressure （81.35 ±3.81 ） mm Hg, body mass index （23.3 ± 1.48）, waist-hip ratio （0.85±0.07）, as well as cholesterol （3.32±0.81）mmol/L triglyceride （1.76±1.01） retool/L, low-density lipoprotein cholesterol （2.20±0.72）mmol/L, high density lipoprotein cholesterol （1.39±0.14） mmol/L, glycosylated hemoglobin （6.58±0.82） mg/dl, （P〈0.05 or P〈0.01）. Conclusion Shengqing-Jiangzhuo decoction significantly improved the clinical efficacy of metabolic syndrome.