铈(Ⅳ)-亚硫酸钠体系化学发光分析法测定卡马西平

Determination of carbamazepine by chemiluminescence analysis with Ce(Ⅳ)-Na_2SO_3 system

目的:建立一种测定片剂卡马西平含量的化学发光分析新方法。方法:在酸性条件下,卡马西平对铈(Ⅳ)和亚硫酸钠弱的化学发光有明显的增敏作用,并结合流动注射技术,建立了流动注射化学发光分析法测定卡马西平的新方法。结果:在优化的实验条件下,增敏的化学发光强度ΔI与卡马西平浓度在1.00×10-8～1.00×10-6g·mL-1的范围内呈良好的线性关系,检出限为6.0×10-9g·mL-1,RSD片剂含量测定;增敏为3.4%(3.0×10-7g·mL-1,n=11),并成功地应用于片剂中卡马西平含量的测定。结论:本方法操作简单且快速,适合于卡马西平的分析。

Objective：To establish a novel chemiluminescence（CL） method for the determination of carbamazepine（CBZ） tablets.Methods：In the acid conditions,it was found that CBZ could significantly enhance the weak CL of the reaction of Ce（Ⅳ） and sodium sulfite.And combining with the flow injection technique,a rapid flow-injection method for the determination of CBZ was developed.Results：Under the optimium conditions,the enhancing CL intensity was linear with the CBZ concentration in the range of 1.00×10-8-1.00×10-6 g·mL-1 with the detection limit of 6.0×10-9 g·mL-1.And RSD was 3.4%（3.0×10-7 g·mL-1,n=11）.The method had successfully applied to determine the content of CBZ tablets.Conclusions：This method is convenient,rapid,and may be considered for the analysis of CBZ.