摘要
中医药发展的根本在于临床疗效,而临床疗效是否显著与药物的生物利用度紧密相关。中药(复方)物质基础的本质是多组分,就组分本身的性质而言,其生物利用度的高低很大程度上取决于组分的生物药剂学性质即溶解性和渗透性。因此,该文将在中医药理论指导下,结合中药现代制剂技术,从物质基础组分的层次阐明改善组分生物药剂学性质关键技术,以期提高中药组分制剂的临床疗效。
The development of traditional Chinese medicine lies in its significant clinical efficacy which is closely related to the bioavailability of drugs. The nature of the material foundation of compounds of traditional Chinese medicine is reflected in multi-compo- nent. As for the nature of components themselves, the level of their bioavailability depends on the biopharmaceutical properties, namely solubility and permeability, to a great extent. Therefore, under the guidance of the theory of traditional Chinese medicine and in the combination with modern preparation techniques, this essay reveals key techniques capable of improving the biopharmaceutical proper- ties of components, in the hope of enhancing the clinical efficacy of components of traditional Chinese medicine.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第19期2993-2996,共4页
China Journal of Chinese Materia Medica
基金
江苏省中医药领军人才项目(2006)
江苏省中医药科技项目(LZ09061)
关键词
物质基础
组分
生物药剂学性质
生物利用度
临床疗效
设计技术
material foundation
component
biopharmaceutical property
bioavailability
clinical efficacy
design technique