正交试验法优选萸丹胶囊的水提工艺

Optimization of Water Extraction Technology of Yudan Capsule by Orthogonal Test

目的:优选萸丹胶囊的水提工艺。方法:以马钱苷、丹酚酸B、绿原酸的综合保留率为评价指标,单因素试验考察提取次数;选取加水量、浸泡时间及煎煮时间为考察因素,采用正交试验设计优选萸丹胶囊的水提工艺。结果:最佳提取工艺为加8倍量水浸泡0.5 h,煎煮1 h,过滤,滤渣加6倍量水煎煮1 h。结论:该优选工艺稳定、合理,可为萸丹胶囊的生产提供实验依据。

Objective： To optimize water extraction technology of Yudan capsule. Method： With comprehensive retention rate of loganin, salvianolic acid B and chlorogenie acid as index, extraction times was optimized by single factor test; the amount of water, soaking time and boiling time were chosen as factors, water extraction technology of Yudan capsule was optimized by orthogonal design. Result： Optimal extraction technology was as follows： soaked 0.5 h with 8 times the amount of water, decocted for 1 h, filtered, residues added 6 folds the amount of water and decocted for 1 h. Conclusion： This optimized extraction technology was stable and reasonable, which provided experimental basis for production of Yudan capsule.