4-甲基环十五烷酮对血管性痴呆大鼠学习记忆力的影响

Effect of 4-methyl-cyclopentadekanone on Learning and Memory in Vascular Dementia Rats

目的:评价4-甲基环十五烷酮对血管性痴呆大鼠学习记忆力的影响。方法:采用大鼠90只,按体重随机分为金纳多注射液(6.1 mg.kg-1)阳性对照组,模型对照组,以及假手术对照组,4-甲基环十五烷酮高、中、低剂量组(8.1,2.7,0.9mg.kg-1)。以结扎双侧颈动脉法造模,各组从造模后7 d开始灌胃给药,每天1次,连续给药28 d,给药体积均为10 mL.kg-1。模型对照组和假手术对照组给予等容量的生理盐水,观察各组实验动物的行为学和脑组织匀浆相关的生化指标。结果:4-甲基环十五烷酮以8.1,2.7 mg.kg-1灌胃时,避暗计数及脑组织匀浆总胆碱酯酶(TChE)活性较模型组明显降低(P<0.05);4-甲基环十五烷酮在8.1 mg.kg-1时,脑组织匀浆超氧化物歧化酶(SOD)活性较模型组明显升高(P<0.05)。结论:4-甲基环十五烷酮对改善血管性痴呆大鼠学习记忆力有一定的作用。

Objective： To evaluate the effect of 4-methyl-cyclopentadekanone on learning and memory in vascular dementia rats. Method： Ninty rats were divided randomly into positive control group （6.1 mg .kg-1 ） , model group, sham operation group, 4-methyl-cyclopentadekanone low, medium and high dose group （8.1, 2.7, 0.9 mg kg-1）. The model was indueced by arteria carotis ligation, and after 7 days these rats were administrated orally once a day for 28 days and given a administration dose at 10 mL kg-1 The model group and sham operation group were administrated normal saline. Related biochemical indicators and praxiology in each group were observed. Result ： Avoiding dark counts and total cholinesterase （TChE） activity degrade obviously （P 〈 0.05） while the intragastric administration was 8. i, 2.7 mg .kg-1, meanwhile the SOD activity increase at a dose of 8. I mg- kg-1 Conclusion： 4-methyl-cyclopentadekanone can enhanee learning and memory in vascular dementia rats.