鸡内金多糖对糖尿病高脂血症大鼠血脂、血糖及细胞免疫功能的影响

Effect of Polysaccharides from Galli Gigerii Endothelium Corneum on Blood Lipid,Blood Glucose and Cellular Immune Function in Diabetes Mellitus Rats with Hyperlipidemia

目的:研究鸡内金多糖(PECG)对糖尿病高脂血症模型的影响。方法:以高脂高糖饲料饲喂Wistar大鼠30 d后,腹腔注射链脲佐菌素,继续以高脂高糖饲料饲喂,并分别以80,20 mg.kg-1剂量的鸡内金多糖灌胃给药40 d,测定血清血脂和血糖水平,计算胸腺指数和脾脏指数,检测淋巴细胞增殖能力,考察PECG对大鼠血脂、血糖及免疫功能的影响。结果:PECG能显著降低糖尿病高脂血症大鼠总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平和空腹血糖浓度(P<0.05),升高高密度脂蛋白胆固醇(HDL-C)、胸腺指数及脾指数(P<0.05),高剂量组大鼠的淋巴细胞转化能力增强,刺激指数(SI)明显升高(P<0.05)。结论:PECG能有效降低糖尿病高脂血症大鼠血糖和血脂水平,并能改善其细胞免疫功能。

Objective： To study the effects of Polysaccharides from Galli Gigerii Endothelium Corneum （PECG） on blood lipid, blood glucose and immune function in diabetes mellitus rats with hypcrlipidemia. Method： Wistar rats were feed with the high fat and sugar feedfor 30 d, thenthe rats was injected with streptozotocin intraperitoneally, continue to feed with high fat and sugar feed, meanwhile, administered orallywith 80, 20 mg kg-1 dosages of PECG for 40 d. Blood lipid, blood glucose and immune function in rats of different groups was observed. The index thymus and spleen were calculated. Result： The levels of total cholesterol （TC） , triaglyceride （TG） , low density lipoprotein cholesterol （LDL-C） and blood glucose decreased significantly （P 〈 0.05） and those of high density lipoprotein cholesterol （HDL-C）, the index thymus and spleen increased greatly （P 〈 0.05） and SI increased obviously in rats of high dose PECG group （P 〈 0.05）. Conclusion： PECG can decrease the level of fasting blood lipid and blood glucose in diabetes mellitus rats with hyperlipidemiaand improved cellular immune function significantly.