扶正消癌汤辅助治疗食管癌术后化疗的疗效观察

Clinical Efficacy Fuzheng Xiao'ai Decoction Treatment for Esophageal Cancer after Chemotherapy

目的:观察扶正消癌汤辅助治疗食管癌术后化疗的临床疗效。方法:将76例食管癌术后患者随机分为治疗组和对照组。对照组37例采用采用5-氟尿嘧啶(5-Fu)、顺铂(DDP)化疗,并作必要的对症处理。治疗组39例,在对照组的基础于术后即开始用扶正消癌汤,疗程12周,观察两组不良反应、KPS评分,并测定血清免疫球蛋白含量。结果:术后及化疗后治疗组在胃排空障碍、腹泻、食欲减退、体重减轻>5%等不良反应发生方面均低于对照组(P<0.05,P<0.01);治疗组在术后1月、化疗结束及化疗结束后2周KPS评分均高于对照组(P<0.01);治疗组治疗后IgG,IgA,IgM水平均高于对照组(P<0.05,P<0.01);治疗后治疗组有效率79.48%,对照组70.27%,两组总疗效相当。结论:扶正消癌汤能减轻食管癌手术及化疗所致不良反应,提高患者生存质量,提高机体免疫力。

Objective： To observe the clinical efficacy of Fuzheng Xiao＇ai decoction （FX） treatment for esophageal cancer after chemotherapy. Method： Seventy-six cases of esophageal cancer after surgery were randomly divided into treatment and control groups. Control group of 37 cases was treated with 5-fluorouracil （5-FU） , cisplatin （DDP）, and with the necessary symptomatic treatment. On the treatment basis of the control group, the treatment group （n = 39） was postoperatively started FX for 12 weeks. The adverse reactions, KPS score, and serum immunoglobulin were observed. Result： The incidences of adverse reactions in treatment group were lower than those in the control group （P 〈0.05, P 〈0.01 ） including the delayed gastric emptying, diarrhea, loss of appetite and the weight loss 〉 5%. After 1 month of treatment, at the end of chemotherapy and two weeks after the end of chemotherapy, KPS score were higher in the treatment group （P 〈0.01 ）. In the treatment group, IgG, IgA, and IgM levels were higher than those in the controls by the end of the treatment （P 〈 0.05, P 〈 0.01 ）. However, the total effective rates in the treatment group and the control group were 79.48% and 70.27% accordingly. Conclusion： FX can reduce the adverse reactions caused by esophageal cancer surgery and chemotherapy to improve patients＇quality of life, improve immune function.