以血管紧张素受体为靶点的药物研究进展

Progress in angiotensin receptor as drug targets

血管紧张素Ⅱ受体共有4种亚型(AT1、AT2、AT3和AT4)。血管紧张素Ⅱ受体拮抗剂是临床上常用的高血压治疗药物,以AT1受体拮抗剂和AT2受体拮抗剂应用较多。近年来,随着对血管紧张素Ⅱ受体拮抗剂研究的深入,涌现出诸多具有良好药理活性的选择性AT1受体拮抗剂、双重作用靶点的非选择性AT1受体拮抗剂和选择性AT2受体拮抗剂。本文对近年来报道的血管紧张素Ⅱ受体拮抗剂进行简要综述。

There are four subtypes of angiotensin ]] receptor （ AT1, AT2, AT3 and AT4 ）. Angiotensin II re- ceptor antagonists have been used as common antihypertensive drugs clinically. AT1 and AT2 receptor an- tagonists have been used as the common drugs in clinic. In recent years, many drugs based on the progress of research on the angiotensin II receptor antagonists, such as selective AT1 ~eceptor antagonists, non-selective AT1 receptor antagonists with two targets and selective AT2 receptor antagonists have been launched. The angiotensin I1 receptor antagonists reported recently were reviewed in this article.