间充质干细胞在急性肺损伤／急性呼吸窘迫综合征中的应用研究进展

~Progress of application of mesenchymal stem cells in acute lung injury/acute respiratory distress syndrome

急性肺损伤／急性呼吸窘迫综合征是一种常见的危重症，是死亡和残疾的主要原因。由于缺乏有效的治疗措施，迄今其病死率仍高达40％。创新治疗是需要的。近年来，随着间充质干细胞技术的研究进展，鉴于间充质干细胞的再生修复、抗炎、免疫调节及抗氧化功能，使间充质干细胞治疗急性肺损伤在理论上具有可行性，并在相关研究中得到证实。然而，其具体治疗机制仍不明，因此间充质干细胞研究已成为热点之一，其可能成为治疗急性肺损伤的一种新途径。

Acute lung injury/acute respiratory distress syndrome is a common in critically ill, is aleading cause of death and disability. Due to the lack of effective treatment, so far, its mortality rate is still as high as 40%. Innovative treatment is needed. In recent years, as the technology advances of mesenehymal stem cells, given the mesenchymal stem cell regeneration, anti inflammatory, immune and antioxidant function, mesenchymal stem cells for treatment of acute lung injury is a theoretical possibility, and confirmed in the study. However, its exact mechanism is still unknown, mesenehymal stem cell research has become one of the hot spots, it may be a new way for treatment of acute lung