PPAR-γ激动剂与β2肾上腺素能受体的脱敏

PPAR-γ agonists and desensitization of β2-adrenoceptors

β2受体激动剂是治疗支气管哮喘的主要药物之一，但长期甚至短期使用都会导致β2受体的脱敏。过氧化物酶体增殖物激活受体γ对新陈代谢和炎症反应过程的基因表达调控起关键性的作用，多个研究表明过氧化物酶体增殖物激活受体了信号通路和口信号通路之间存在相互影响。

β2-adrenoceptor agonists represent one of the most important drug classes in the treatment of asthma. Unfortunately, both long-term and short-term treatments with these drugs are known to induce receptor desensitization. Peroxisome proliferator-activated receptors γ（PPAR-γ） play a pivotal role in controlling the expression of genes involved in metabolic and inflammatory processes. Several researches demonstrated the existence of cross-talk between PPAR-γ signal transduction pathways and β-adrenoceptor signalling pathways.