摘要
β2受体激动剂是治疗支气管哮喘的主要药物之一,但长期甚至短期使用都会导致β2受体的脱敏。过氧化物酶体增殖物激活受体γ对新陈代谢和炎症反应过程的基因表达调控起关键性的作用,多个研究表明过氧化物酶体增殖物激活受体了信号通路和口信号通路之间存在相互影响。
β2-adrenoceptor agonists represent one of the most important drug classes in the treatment of asthma. Unfortunately, both long-term and short-term treatments with these drugs are known to induce receptor desensitization. Peroxisome proliferator-activated receptors γ(PPAR-γ) play a pivotal role in controlling the expression of genes involved in metabolic and inflammatory processes. Several researches demonstrated the existence of cross-talk between PPAR-γ signal transduction pathways and β-adrenoceptor signalling pathways.
出处
《国际呼吸杂志》
2012年第18期1402-1405,共4页
International Journal of Respiration
基金
国家自然科学基金(No:30971306)
江苏省六大人才高峰项目(第七批次,No:033)