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新辅助化疗在晚期上皮性卵巢癌病例治疗中的作用 被引量:5

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摘要 目的:探讨新辅助化疗方案在晚期上皮性卵巢癌患者中的治疗效果。方法:系统性回顾42例晚期上皮性卵巢癌患者的临床资料,其中20例患者采用新辅助化疗(NAC),22例患者接受手术治疗,比较二者的手术满意率。结果:NAC组于手术中见病灶部位有坏死,肿瘤易剥离,相对容易切除。术后标本病理学镜检显示肿瘤细胞有不同程度的退行性改变,部分病例切除病灶组织学完全消退。实施肿瘤细胞减灭术后,NAC组(75.00%)远高于PCS组(45.45%),经统计学分析具有差异性(P<0.05)。结论:卵巢癌晚期患者临床上判断行手术治疗比较困难,采用新辅助化疗后可使手术成功率提高,并可有效降低患者术中并发症的发生概率。
机构地区 辽宁省肿瘤医院
出处 《亚太传统医药》 2012年第10期164-165,共2页 Asia-Pacific Traditional Medicine
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参考文献4

  • 1吴化平,颉彦华,赵其景,秦英.卵巢癌对顺铂耐药机制的研究进展[J].中国肿瘤临床,2006,33(21):1256-1259. 被引量:12
  • 2DEFFIEUX X, CASTAIGNE D, POMEL C. Role of laparos- copy to evaluate candidates for complete cytoreduction in ad- vanced stages of epithelial ovarian cancer[J]. Int J Gynecol Cancer,2006,16(1):35-40.
  • 3王晓平,王晓娟,栾汛,韩靖.新辅助化疗在晚期卵巢癌治疗中的作用[J].中国肿瘤临床,2007,34(8):465-466. 被引量:11
  • 4KUHN W, RUTKE S,SPPATHE K, et al. Neoadjuvant chemo- therapy followed by tumor debulking prolongs survial for patients with poor prog-nosis in internation federation of gynecology and obstetrics stage III ovarian carcinoma[J]. Cancer, 2008,92 (10): 2585-2591.

二级参考文献33

  • 1赵晓东,张毅.晚期卵巢上皮癌新辅助化疗[J].国外医学(肿瘤学分册),2005,32(4):310-313. 被引量:7
  • 2马丁,韩晓兵.卵巢癌的先期化疗[J].实用妇产科杂志,2005,21(5):263-264. 被引量:3
  • 3吴化平,颉彦华,赵其景,秦英.卵巢癌对顺铂耐药机制的研究进展[J].中国肿瘤临床,2006,33(21):1256-1259. 被引量:12
  • 4Mozzetti S,Ferlini C,Concolino P,et al.Class Ⅲ beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients[J].Clin Cancer Res,2005,11 (1):298~305
  • 5Yakirevich E,Sabo E,Naroditsky I,et al.Multidrug resistance-related henotype and apoptosis-related protein expression in ovarian serous carcinomas[J].Gynecol Oncol,2006,100(1):152~159
  • 6Tsuruo T,Inda H,Tsukagoshi S.Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil[J].Cancer Res,1981,41(5):1967~1972
  • 7Moran E,Cleary I,Larkin AM.Co-expression of MDR-associated markers,including P-170,MRP and LRP and Cytoskeletal proteins,in three resistant variants of the human ovarian carcinoma cell line,OAW42[J].Eur J Cancer,1997,33(4):652~660
  • 8Hendrikse NH,Franssen EJF,WTA van der Graaf.Vissalization of multidrug resistance in vivo[J].Eur J Nucl Med,1999,26(3):283~293
  • 9Cheng TC,Manorek G,Samimi G,et al.Identification of genes whose expression is associated with cisplatin resistance in human ovarian carcinoma cells[J].Cancer Chemother Pharmacol,2006,58(3):384~395
  • 10Versantvoort CH,Broxterman HJ,Bagrij T,et al.Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein[J].BrJ Cancer,1995,72(1):82~89

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