不同三联疗法治疗消化性溃疡的疗效观察

The efficacy observation of different triple therapy for treating peptic ulcer

目的观察不同三联疗法治疗消化性溃疡的疗效。方法 80例幽门螺杆菌性消化道溃疡患者随机平分为2组,治疗组与对照组各40例,治疗组给予雷贝拉唑、克拉霉素和左氧氟沙星联合治疗,对照组给予奥美拉唑、克拉霉素和左氧氟沙星联合治疗。结果经过治疗后,治疗组总有效率为95.0%,对照组总有效率为65.0%,说明治疗组临床总体疗效明显优于对照组(P<0.05)。治疗组幽门螺杆菌(HP)清除率为97.5%(39/40),对照组Hp清除率为87.5%(35/40),治疗组的Hp清除率明显高于对照组,两组比较差异有统计学意义(P<0.05)。结论雷贝拉唑、克拉霉素和左氧氟沙星治疗幽门螺杆菌消化道溃疡疗效好,可更有效地根除Hp,值得进一步研究及推广。

Objective To observe efficacy of different triple therapy for treating peptic ulcer.Methods 80 cases of helicobacter pylori peptic ulcer patients were randomly divided into two groups-the treatment group and control group,the treatment group received rabeprazole,clarithromycin and levofloxacin combination therapy,the control group received omeprazole,clarithromycin and levofloxacin combination therapy.Results After treatment,total effective rate was 95.0% in the treatment group,the total effective rate was 65.0% in the control group,indicated that the overall clinical efficacy of the treatment group were better than the control group（P0.05）.the treatment group Hp clearance rate was 97.5%（39/40）,so that was 87.5%（35/40） in the control group,the difference was statistically significant（P0.05）.Conclusion rabeprazole,clarithromycin and levofloxacin in the treatment efficacy of Helicobacter pylori peptic ulcer,and can be more effective in eradicating Hp,worthy of further research and promotion.