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放射增敏剂尼可胺对雄性大鼠生殖毒性的研究

The reproductive toxicity of NiKeAn in male rats
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摘要 目的观察尼可胺对雄性大鼠生殖能力的影响。方法将100只健康成年雄性Wistar大鼠随机分为4组:空白对照组(O.9%氯化钠注射液)、尼可胺高剂量组(300mg/kg)、尼克胺中剂量组200mg/kg)和尼克胺低剂量组(100mg/kg)。雄性大鼠连续尾静脉注射给药5周后(每日1次),与100只雌性Wistar大鼠随机1:1合笼交配,交配后处死雄性大鼠,检查尼可胺对各剂量组雄性大鼠的交配率、精子数量、精子活率、精子活力、脏器系数的影响及睾丸、附睾的组织病理学变化。结果200mg/kg以下剂量对成年雄性大鼠检测的生育指标无明显影响。结论200mg/kg以下剂量对成年雄性大鼠的牛殖功能无明显毒性作用。 Objective To observe the toxic effects of NiKeAn on the ability of reproduction in male rats. Methods One hundred health adult Wistar rats were randomly divided into 4 groups with 25 in each group. The rats of control groups were given intravenous injections with normal saline and the experimental groups received NiKeAn at doses of 300 mg/kg, 200 mg/kg and 100 mg/kg once per day. All rats were injected for 5 weeks then mated and executed. The coefficient of testicle and epididymis, mating rate, sperm, the per- centage of motile sperm, and histopathological changes of testicle and cpididymis were detected. Results Under doses of 200 mg/kg concentration of NiKeAn used in this study have no significant influence on the aforementioned parameters. Conclusion Under doses of 200 mg/kg, reproductive function of male rats does not obviously impaired by NiKeAn.
出处 《国际放射医学核医学杂志》 2012年第5期293-296,共4页 International Journal of Radiation Medicine and Nuclear Medicine
基金 天津市科技支撑计划重点项目(09ZCKFSH01500)
关键词 生殖毒性 大鼠 WISTAR 尼可胺 Preconception injuries Rats, Wistar NiKeAn
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