放射增敏剂尼可胺对雄性大鼠生殖毒性的研究

The reproductive toxicity of NiKeAn in male rats

目的观察尼可胺对雄性大鼠生殖能力的影响。方法将100只健康成年雄性Wistar大鼠随机分为4组：空白对照组（O．9％氯化钠注射液）、尼可胺高剂量组（300mg／kg）、尼克胺中剂量组200mg／kg）和尼克胺低剂量组（100mg／kg）。雄性大鼠连续尾静脉注射给药5周后（每日1次），与100只雌性Wistar大鼠随机1：1合笼交配，交配后处死雄性大鼠，检查尼可胺对各剂量组雄性大鼠的交配率、精子数量、精子活率、精子活力、脏器系数的影响及睾丸、附睾的组织病理学变化。结果200mg／kg以下剂量对成年雄性大鼠检测的生育指标无明显影响。结论200mg／kg以下剂量对成年雄性大鼠的牛殖功能无明显毒性作用。

Objective To observe the toxic effects of NiKeAn on the ability of reproduction in male rats. Methods One hundred health adult Wistar rats were randomly divided into 4 groups with 25 in each group. The rats of control groups were given intravenous injections with normal saline and the experimental groups received NiKeAn at doses of 300 mg/kg, 200 mg/kg and 100 mg/kg once per day. All rats were injected for 5 weeks then mated and executed. The coefficient of testicle and epididymis, mating rate, sperm, the per- centage of motile sperm, and histopathological changes of testicle and cpididymis were detected. Results Under doses of 200 mg/kg concentration of NiKeAn used in this study have no significant influence on the aforementioned parameters. Conclusion Under doses of 200 mg/kg, reproductive function of male rats does not obviously impaired by NiKeAn.